PMID- 35642292
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220716
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 28
DP  - 2022 Jan-Dec
TI  - The Association Between Mean Corpuscular Hemoglobin Concentration and Prognosis 
      in Patients with Acute Pulmonary Embolism: A Retrospective Cohort Study.
PG  - 10760296221103867
LID - 10.1177/10760296221103867 [doi]
LID - 10760296221103867
AB  - INTRODUCTION: Acute pulmonary embolism (APE) is a typical cardiovascular 
      emergency worldwide. Mean hemoglobin concentration (MCHC) is a standard indicator 
      of anemia. Studies on the association between MCHC and APE are scarce. We aimed 
      to investigate the relationship between MCHC and APE. METHODS: Clinical data were 
      extracted from the Medical Information Bank for Intensive Care (MIMIC)-III. Adult 
      (>/=18 years) patients with APE admitted for the first time were included in this 
      study. An analysis was conducted to evaluate the association between MCHC and the 
      prognosis of patients by the Cox regression analysis, generalized additives 
      models and Kaplan-Meier survival curves. The primary outcome was 30-day 
      mortality, and the secondary outcomes were 1-year and 3-year mortality. RESULTS: 
      A total of 813 patients who met the selection criteria were enrolled, of whom 130 
      (16.0%) died within 30 days of admission. Univariate Cox regression indicated 
      that MCHC was significantly associated with mortality (30-day: HR = 0.74, 95% 
      CI = 0.66-0.82, P < 0.001; 1-year: HR = 0.80, 95% CI = 0.74-0.86, P < 0.001; 
      3-year: HR = 0.82, 95% CI = 0.77-0.88, P < 0.001). MCHC remains stable after 
      adjusting multiple models. Kaplan-Meier survival curves showed that patients with 
      lower MCHC had a poorer 30-day prognosis. CONCLUSIONS: Lower MCHC is an 
      independent risk factor for increased mortality in patients with APE. As an 
      inexpensive biomarker, MCHC should receive more attention.
FAU - Ruan, Zhishen
AU  - Ruan Z
AD  - The First Clinical College, 74738Shandong Chinese Medical University, Ji Nan, 
      People's Republic of China.
FAU - Li, Dan
AU  - Li D
AD  - The First Clinical College, 74738Shandong Chinese Medical University, Ji Nan, 
      People's Republic of China.
FAU - Hu, Yuanlong
AU  - Hu Y
AD  - The First Clinical College, 74738Shandong Chinese Medical University, Ji Nan, 
      People's Republic of China.
FAU - Qiu, Zhanjun
AU  - Qiu Z
AD  - Department of Pulmonary and Critical Care Medicine, 159393The First Affiliated 
      Hospital of Shandong Chinese Medical University, Ji Nan, People's Republic of 
      China.
FAU - Chen, Xianhai
AU  - Chen X
AD  - Department of Pulmonary and Critical Care Medicine, 159393The First Affiliated 
      Hospital of Shandong Chinese Medical University, Ji Nan, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - *Erythrocyte Indices
MH  - Humans
MH  - Prognosis
MH  - *Pulmonary Embolism
MH  - Retrospective Studies
PMC - PMC9163730
OTO - NOTNLM
OT  - acute pulmonary embolism
OT  - hematological parameter
OT  - mean corpuscular hemoglobin concentration
OT  - prognosis
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2022/06/02 06:00
MHDA- 2022/06/03 06:00
PMCR- 2022/05/31
CRDT- 2022/06/01 02:03
PHST- 2022/06/01 02:03 [entrez]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2022/05/31 00:00 [pmc-release]
AID - 10.1177_10760296221103867 [pii]
AID - 10.1177/10760296221103867 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221103867. doi: 
      10.1177/10760296221103867.