PMID- 35643295 OWN - NLM STAT- MEDLINE DCOM- 20220907 LR - 20220907 IS - 1879-8519 (Electronic) IS - 1879-8500 (Linking) VI - 12 IP - 5 DP - 2022 Sep-Oct TI - Patient-Reported Sexual Function in Long-Term Survivors of Anal Cancer Treated With Definitive Intensity Modulated Radiation Therapy and Concurrent Chemotherapy. PG - e397-e405 LID - S1879-8500(22)00157-6 [pii] LID - 10.1016/j.prro.2022.05.006 [doi] AB - PURPOSE: Pelvic chemoradiation can have a profound effect on sexual function. Few data exist describing long-term sexual function patient-reported outcomes (PROs) for patients treated with intensity modulated radiation and concurrent chemotherapy (CRT) for squamous cell carcinoma of the anus (SCCA). METHODS AND MATERIALS: We identified 248 patients with SCCA treated with CRT from 2010 to 2018 who were alive and without recurrence. We sent a PRO survey to 148 patients who agreed to participate. The survey was comprised of the PROMIS sexual function and satisfaction questionnaire, the international index of erectile function 5-item questionnaire for men, and the female sexual function index questionnaire for women. Clinical and dosimetric data were collected for each patient. We used multiple regression models to identify factors associated with sexual function PROs. RESULTS: One-hundred twelve patients (45.2% of all eligible patients, 75.7% of administered surveys) completed the survey; 90 (80.4%) were women, 107 (95.5%) were white. The median (interquartile range [IQR]) age was 61.5 (53.8-66.0) years. The median (IQR) interval since CRT was 51 (37-85) months. Twelve men (54.5%) and 52 women (57.1%) were sexually active. The median (IQR) age of sexually active patients was 58.2 (50.1-64) years compared with 64.8 (59.1-68.8) years for sexually inactive patients (P < .001). The median (IQR) female sexual function index score for sexually active women was 20.2 (13.6-25.1). The median (IQR) international index of erectile function 5-item questionnaire score was 14 (6.5-19). CONCLUSIONS: Patients treated with modern CRT for SCCA experience significant long-term sexual dysfunction as reported using validated PROs. Interventions to reduce sexual toxicities and improve patient support are needed. CI - Copyright (c) 2022 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved. FAU - Corrigan, Kelsey L AU - Corrigan KL AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Rooney, Michael K AU - Rooney MK AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - De, Brian AU - De B AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Ludmir, Ethan D AU - Ludmir ED AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas; Departments of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Das, Prajnan AU - Das P AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Smith, Grace L AU - Smith GL AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Taniguchi, Cullen AU - Taniguchi C AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Minsky, Bruce D AU - Minsky BD AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Koay, Eugene J AU - Koay EJ AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Koong, Albert AU - Koong A AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Morris, Van K AU - Morris VK AD - Departments of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Messick, Craig A AU - Messick CA AD - Departments of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Nogueras-Gonzalez, Graciela AU - Nogueras-Gonzalez G AD - Departments of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Holliday, Emma B AU - Holliday EB AD - Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ebholliday@mdanderson.org. LA - eng PT - Journal Article DEP - 20220525 PL - United States TA - Pract Radiat Oncol JT - Practical radiation oncology JID - 101558279 SB - IM MH - Aged MH - *Anus Neoplasms/radiotherapy MH - *Carcinoma, Squamous Cell MH - *Erectile Dysfunction MH - Female MH - Humans MH - Male MH - Middle Aged MH - Patient Reported Outcome Measures MH - *Sexual Dysfunction, Physiological/epidemiology/etiology MH - Survivors EDAT- 2022/06/02 06:00 MHDA- 2022/09/08 06:00 CRDT- 2022/06/01 09:23 PHST- 2021/09/27 00:00 [received] PHST- 2022/03/15 00:00 [revised] PHST- 2022/05/17 00:00 [accepted] PHST- 2022/06/02 06:00 [pubmed] PHST- 2022/09/08 06:00 [medline] PHST- 2022/06/01 09:23 [entrez] AID - S1879-8500(22)00157-6 [pii] AID - 10.1016/j.prro.2022.05.006 [doi] PST - ppublish SO - Pract Radiat Oncol. 2022 Sep-Oct;12(5):e397-e405. doi: 10.1016/j.prro.2022.05.006. Epub 2022 May 25.