PMID- 35643343
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 83
DP  - 2022 Sep
TI  - Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and 
      in vivo.
PG  - 105395
LID - S0887-2333(22)00092-3 [pii]
LID - 10.1016/j.tiv.2022.105395 [doi]
AB  - Dendritic cells (DCs) are powerful antigen presentation cells and the initiator 
      of adaptive immune response. Cimetidine, a widely used drug for gastric ulcers 
      treatment, has significant immunomodulatory ability. However, the effects of 
      cimetidine on DC-mediated T cell activation need to be further explored. In this 
      study, we constructed the in vitro and in vivo model of cimetidine exposure, and 
      our data showed that cimetidine stimulated the maturity of immature DCs, and 
      further enhanced its T cell priming capacity. In vivo, the number of rat splenic 
      CD103(+) DC were not altered after cimetidine exposure, but the expression of 
      surface markers CD54, CD11c, and MHC-II of which were up-regulated. Importantly, 
      cimetidine interfered with DC-mediated T cell polarization, which was reflected 
      in the up-regulation of Th1 and Th17 cells and the down-regulation of Th2 and 
      Treg cells in vitro and in vivo. These results indicate that cimetidine can 
      induce DC activation and promote DC mediated pro-inflammatory T cell response 
      while weaken immunosuppressive T cell response.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Qu, Yaqian
AU  - Qu Y
AD  - Department of Occupational Health and Occupational Disease, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Bao, Lei
AU  - Bao L
AD  - School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, PR China.
FAU - Zhao, Youliang
AU  - Zhao Y
AD  - Department of Occupational Health and Occupational Disease, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Li, Yiping
AU  - Li Y
AD  - Department of Occupational Health and Occupational Disease, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Ding, Mingcui
AU  - Ding M
AD  - Department of Occupational Health and Occupational Disease, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Hao, Changfu
AU  - Hao C
AD  - Department of Occupational Health and Occupational Disease, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: 
      haochangfu@126.com.
FAU - Yao, Wu
AU  - Yao W
AD  - Department of Occupational Health and Occupational Disease, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: 
      yaowu@zzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220526
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - 80061L1WGD (Cimetidine)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - *Cimetidine/metabolism/pharmacology
MH  - Dendritic Cells/metabolism
MH  - Lymphocyte Activation
MH  - Rats
MH  - *Th17 Cells
OTO - NOTNLM
OT  - Cimetidine
OT  - Dendritic cells
OT  - Immunomodulatory
OT  - T cell polarization
EDAT- 2022/06/02 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/06/01 09:24
PHST- 2022/01/15 00:00 [received]
PHST- 2022/04/27 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/06/01 09:24 [entrez]
AID - S0887-2333(22)00092-3 [pii]
AID - 10.1016/j.tiv.2022.105395 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2022 Sep;83:105395. doi: 10.1016/j.tiv.2022.105395. Epub 2022 
      May 26.