PMID- 35644410
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220917
IS  - 1089-8646 (Electronic)
IS  - 0888-7543 (Linking)
VI  - 114
IP  - 4
DP  - 2022 Jul
TI  - A 5'-tiRNA fragment that inhibits proliferation and migration of laryngeal 
      squamous cell carcinoma by targeting PIK3CD.
PG  - 110392
LID - S0888-7543(22)00137-9 [pii]
LID - 10.1016/j.ygeno.2022.110392 [doi]
AB  - tRNA-derived small RNAs (tsRNAs) participate in several biological processes, 
      including carcinogenesis. The correlations between tsRNAs and human cancers are 
      attracting substantial attention. Nevertheless, the involvement of tsRNAs in 
      laryngeal squamous cell carcinoma (LSCC) progression remains unclear. We 
      constructed tsRNAs expression profiles in LSCC and adjacent normal tissues by 
      next-generation sequencing. Interestingly, we identified a specific 5'-tiRNA 
      fragment (tRF-33-Q1Q89P9L842205) that was significantly downregulated and was 
      closely associated with lymph node metastasis and advanced stages of LSCC. 
      Importantly, we found that tRF-33-Q1Q89P9L842205 suppressed cell growth, 
      proliferation, migration, invasion and induced apoptosis in LSCC by directly 
      silencing phosphoinositide 3-kinase catalytic subunit (PIK3CD). We speculated 
      that tRF-33-Q1Q89P9L842205 is a potential diagnostic biomarker for LSCC and acts 
      as a tumor suppressor by directly targeting PIK3CD.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Deng, Hongxia
AU  - Deng H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Wang, Jianing
AU  - Wang J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital 
      affiliated to Ningbo University, Ningbo, Zhejiang, China.
FAU - Ye, Dong
AU  - Ye D
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Chen, Jingjing
AU  - Chen J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Qiu, Shijie
AU  - Qiu S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Tang, Ming
AU  - Tang M
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Zhou, Chongchang
AU  - Zhou C
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Shen, Yi
AU  - Shen Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China.
FAU - Fang, Shuai
AU  - Fang S
AD  - Department of Thoracic Surgery, The Affiliated Hospital of Ningbo University 
      School of Medicine, Ningbo, China.
FAU - Shen, Zhisen
AU  - Shen Z
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China. Electronic address: szs7216@163.com.
FAU - Gu, Shanshan
AU  - Gu S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang, China; Department of Otorhinolaryngology Head 
      and Neck Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, 
      Zhejiang, China. Electronic address: gushanshan@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220526
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (MicroRNAs)
RN  - EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.1.137 (PIK3CD protein, human)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - *Class I Phosphatidylinositol 3-Kinases/genetics/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics/metabolism/pathology
MH  - *MicroRNAs/metabolism
MH  - *Squamous Cell Carcinoma of Head and Neck/genetics
OTO - NOTNLM
OT  - 5'-tiRNA fragment
OT  - Laryngeal squamous cell carcinoma
OT  - PIK3CD
OT  - tRF-33-Q1Q89P9L842205
OT  - tRNA-derived small RNAs
EDAT- 2022/06/02 06:00
MHDA- 2022/08/24 06:00
CRDT- 2022/06/01 10:34
PHST- 2022/01/04 00:00 [received]
PHST- 2022/04/24 00:00 [revised]
PHST- 2022/05/22 00:00 [accepted]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2022/06/01 10:34 [entrez]
AID - S0888-7543(22)00137-9 [pii]
AID - 10.1016/j.ygeno.2022.110392 [doi]
PST - ppublish
SO  - Genomics. 2022 Jul;114(4):110392. doi: 10.1016/j.ygeno.2022.110392. Epub 2022 May 
      26.