PMID- 35646552
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2212-4268 (Print)
IS  - 2212-4276 (Electronic)
IS  - 2212-4268 (Linking)
VI  - 12
IP  - 4
DP  - 2022 Jul-Aug
TI  - The influence of diabetes mellitus on the peri-implant microflora: A 
      cross-sectional study.
PG  - 405-409
LID - 10.1016/j.jobcr.2022.05.007 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is an important systemic disease, 
      predisposing patients to inflammatory conditions including periodontitis and 
      peri-implantitis and negatively affects dental implant success through various 
      mechanisms. This study aimed to compare clinical and microbiological findings of 
      individuals with dental implants with or without T2DM. METHODS: A total of 82 
      dental implants which were in function >3 years, were involved. The participants 
      were divided into 2 groups; T2DM (n: 45 implants) and systemically healthy 
      controls (n:37 implants). Periodontal indexes (Bleeding on probing (BOP), plaque 
      index (PI), pocket depth (PD), and radiographic bone loss were recorded around 
      implants in function >3 years. Subgingival microbiological samples were also 
      collected from the peri-implant sites. Pathogens include Fusobacterium nucleatum, 
      Camphylobacter rectus, Porphyromonas gingivalis, Tannerella forsythia, 
      Actinobacillus actinomycetemcomitans, Treponema denticola, Prevotella intermedia, 
      Peptostreptococcus micros, Eikinella corrodens, Prevotella nigrescens were 
      evaluated. RESULTS: Peri-implant heatlh was determined in systemically healthy 
      (54.1%) and type 2 diabetes patients (24.4%). Peri-implantitis was also evident 
      in systemically healthy (8.1%) and T2DM (35.6%) groups. No differences was found 
      in shallow peri-implant pockets in both groups in terms of the prevelance of all 
      evaluated bacteria (p > 0.05). However, C. rectus, P. gingivalis, A. 
      actinomycetemcomitans and T. forsythia were isolated more frequently in deep 
      peri-implant pockets in systemically healthy patients compared to T2DM patients 
      (p < 0.05). CONCLUSIONS: Evaluted periodontal pathogens may not be affected by 
      the presence of T2DM in implants. T2DM may not significantly alter the levels of 
      specific periodontal pathogens in shallow and deep peri-implant pockets. C. 
      rectus, P. gingivalis, A. actinomycetemcomitans and T. forsythia may be affected 
      by T2DM in implants in deep pockets.
CI  - (c) 2022 Craniofacial Research Foundation. Published by Elsevier B.V. All rights 
      reserved.
FAU - Sabanci, Arife
AU  - Sabanci A
AD  - Department of Periodontology, Inonu University, Malatya, Turkey.
FAU - Eltas, Abubekir
AU  - Eltas A
AD  - Department of Periodontology, University of Health Science, Istanbul, Turkey.
FAU - Celik, Betul
AU  - Celik B
AD  - Department of Biological Sciences, Delaware University, Newark, DE, 19716, USA.
FAU - Otlu, Baris
AU  - Otlu B
AD  - Department of Medical Microbiology, Inonu University, Malatya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220517
PL  - Netherlands
TA  - J Oral Biol Craniofac Res
JT  - Journal of oral biology and craniofacial research
JID - 101619156
PMC - PMC9136106
OTO - NOTNLM
OT  - Dental implant
OT  - Diabetes mellitus
OT  - Microflora
OT  - Peri-implant pocket
COIS- There is no conflict of interest for this study.
EDAT- 2022/06/02 06:00
MHDA- 2022/06/02 06:01
PMCR- 2022/05/17
CRDT- 2022/06/01 11:38
PHST- 2022/02/28 00:00 [received]
PHST- 2022/05/14 00:00 [accepted]
PHST- 2022/06/01 11:38 [entrez]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/02 06:01 [medline]
PHST- 2022/05/17 00:00 [pmc-release]
AID - S2212-4268(22)00047-1 [pii]
AID - 10.1016/j.jobcr.2022.05.007 [doi]
PST - ppublish
SO  - J Oral Biol Craniofac Res. 2022 Jul-Aug;12(4):405-409. doi: 
      10.1016/j.jobcr.2022.05.007. Epub 2022 May 17.