PMID- 35647060
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Longitudinal Associations Between Cumulative Physical Activity and Change in 
      Structure and Function of the Left Side of the Heart: The Tromso Study 2007-2016.
PG  - 882077
LID - 10.3389/fcvm.2022.882077 [doi]
LID - 882077
AB  - BACKGROUND: Current knowledge about the relationship between physical activity 
      (PA) and cardiac remodeling is mainly derived from cross-sectional studies of 
      athletes, and there is a knowledge gap of this association in the general adult 
      and elderly population. Therefore, we aimed to explore the longitudinal 
      association between cumulative PA and change in cardiac structure and function in 
      a general adult and elderly population. METHODS: This longitudinal study includes 
      594 participants from the sixth (Tromso6, 2007-08) and seventh (Tromso7, 2015-16) 
      survey of the Tromso Study. Cardiac structure and function were assessed by 
      echocardiography at two time points, and PA was self-reported by questionnaire at 
      both time points. PA volume was expressed as cumulative PA (Low, Moderate, and 
      Hard) and the association with left atrial (LA) and left ventricular (LV) 
      structure and function was assessed using ANCOVA. RESULTS: Overall, LA diameter 
      index (LADi) increased significantly more in Hard compared to Moderate PA (+0.08 
      cm/m(2), 95% CI 0.01-0.15, p = 0.020) from Tromso6 to Tromso7. When stratified by 
      sex or age, higher levels of cumulative PA were associated with increased LADi in 
      males and in participants <65 years only. Indexed LV mass (LVMi) increased 
      significantly more in Moderate than in Low PA (+3.9 g/m(2.7), 95% CI 0.23-7.57, p 
      = 0.037). When stratified by sex or age, these changes in LVMi and indexed LV 
      diameter (LVDi) were only significant in females. No significant associations 
      were observed between cumulative PA and change in relative wall thickness, E/e' 
      ratio, e' velocity, LV ejection fraction, and LADi/LVDi ratio. CONCLUSION: Higher 
      levels of cumulative PA were associated with increased LADi in males and 
      participants <65 years, and with increased LVMi and LVDi in females. Despite 
      cardiac chamber enlargement, the pump function of the heart did not change with 
      higher levels of PA, and the atrioventricular ratio was unchanged. Our results 
      indicate that cardiac chamber enlargement is a physiological response to PA.
CI  - Copyright (c) 2022 Heitmann, Welde, Lochen, Stylidis, Schirmer and Morseth.
FAU - Heitmann, Kim Arne
AU  - Heitmann KA
AD  - School of Sport Sciences, UiT The Arctic University of Norway, Tromso, Norway.
AD  - Centre for Research and Education, University Hospital of Northern Norway, 
      Tromso, Norway.
FAU - Welde, Boye
AU  - Welde B
AD  - School of Sport Sciences, UiT The Arctic University of Norway, Tromso, Norway.
FAU - Lochen, Maja-Lisa
AU  - Lochen ML
AD  - Department of Community Medicine, UiT The Arctic University of Norway, Tromso, 
      Norway.
FAU - Stylidis, Michael
AU  - Stylidis M
AD  - Department of Community Medicine, UiT The Arctic University of Norway, Tromso, 
      Norway.
FAU - Schirmer, Henrik
AU  - Schirmer H
AD  - Department of Cardiology, Akershus University Hospital, Lorenskog, Norway.
AD  - Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
AD  - Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, 
      Norway.
FAU - Morseth, Bente
AU  - Morseth B
AD  - School of Sport Sciences, UiT The Arctic University of Norway, Tromso, Norway.
AD  - Centre for Research and Education, University Hospital of Northern Norway, 
      Tromso, Norway.
LA  - eng
PT  - Journal Article
DEP - 20220512
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9133513
OTO - NOTNLM
OT  - athlete's heart
OT  - cardiac
OT  - echocardiography
OT  - ejection fraction
OT  - exercise
OT  - left atrium
OT  - left ventricle
OT  - public health
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/02 06:00
MHDA- 2022/06/02 06:01
PMCR- 2022/01/01
CRDT- 2022/06/01 11:43
PHST- 2022/02/23 00:00 [received]
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/06/01 11:43 [entrez]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/02 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.882077 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 May 12;9:882077. doi: 10.3389/fcvm.2022.882077. 
      eCollection 2022.