PMID- 35647704
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220823
IS  - 2041-3033 (Electronic)
IS  - 0954-4119 (Linking)
VI  - 236
IP  - 8
DP  - 2022 Aug
TI  - Comparison of the design maps of TPMS based bone scaffolds using a computational 
      modeling framework simultaneously considering various conditions.
PG  - 1157-1168
LID - 10.1177/09544119221102704 [doi]
AB  - In recent years, the triply periodic minimal surface (TPMS)-based scaffolds have 
      been served as one of the crucial types of structures for biological 
      replacements, the energy absorber, etc. Meanwhile, the development of additive 
      manufacturing (AM) has facilitated the production of TPMS scaffolds with complex 
      microstructures. However, the design maps of TPMS scaffolds, especially 
      considering the AM constraints, remain unclear, which has hindered the design and 
      application of TPMS scaffolds. The aims of the present study were to develop an 
      efficient computational modeling framework for investigating the design maps of 
      TPMS scaffolds simultaneously considering the AM constraints, the biological 
      requirements, and the structural anisotropy. To demonstrate the computational 
      framework, five widely-used topologies of the TPMS-based scaffolds (i.e. the 
      Diamond, the Gyroid, the Fischer-Koch S, the F-RD, and the Schwarz P) were used, 
      whose design maps for the surface-to-volume ratio and the effective elastic 
      modulus were also investigated. The results showed that as the porosities 
      increase, the design ranges of the surface-to-volume ratios decreases for all the 
      structures. Compared with the effect of the constraint for the pore size, the 
      minimal structural thickness for AM constraint has a greater effect on the 
      surface-to-volume ratio. Regarding the elastic modulus, in the region of low 
      porosity (approximately 0.5-0.7), the range for the effective elastic modulus of 
      Schwarz P is the widest (approximately 2.24-32.6 GPa), but the Gyroid can achieve 
      both high porosity and low effective elastic modulus (e.g. 0.61 GPa at the 
      porosity of 0.90). These results and the method developed in the present study 
      provided important basis and guidance for the design and application of the 
      TPMS-based porous structures.
FAU - Lu, Yongtao
AU  - Lu Y
AUID- ORCID: 0000-0002-8511-6111
AD  - Department of Engineering Mechanics, Dalian University of Technology, Dalian, 
      China.
AD  - DUT-BSU Joint Institute, Dalian University of Technology, Dalian, China.
FAU - Huo, Yi
AU  - Huo Y
AD  - Department of Engineering Mechanics, Dalian University of Technology, Dalian, 
      China.
FAU - Zou, Jia'ao
AU  - Zou J
AD  - Department of Engineering Mechanics, Dalian University of Technology, Dalian, 
      China.
FAU - Li, Yanchen
AU  - Li Y
AD  - Department of Engineering Mechanics, Dalian University of Technology, Dalian, 
      China.
FAU - Yang, Zhuoyue
AU  - Yang Z
AUID- ORCID: 0000-0001-9353-6426
AD  - Department of Engineering Mechanics, Dalian University of Technology, Dalian, 
      China.
FAU - Zhu, Hanxing
AU  - Zhu H
AD  - School of Engineering, Cardiff University, Cardiff, UK.
FAU - Wu, Chengwei
AU  - Wu C
AD  - Department of Engineering Mechanics, Dalian University of Technology, Dalian, 
      China.
AD  - State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian 
      University of Technology, Dalian, China.
LA  - eng
PT  - Journal Article
DEP - 20220601
PL  - England
TA  - Proc Inst Mech Eng H
JT  - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of 
      engineering in medicine
JID - 8908934
SB  - IM
MH  - Bone and Bones
MH  - Computer Simulation
MH  - Porosity
MH  - *Tissue Engineering/methods
MH  - *Tissue Scaffolds/chemistry
OTO - NOTNLM
OT  - TPMS scaffold
OT  - additive manufacturing
OT  - computational modeling
OT  - design map
OT  - mechanical property
EDAT- 2022/06/02 06:00
MHDA- 2022/08/24 06:00
CRDT- 2022/06/01 11:54
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2022/06/01 11:54 [entrez]
AID - 10.1177/09544119221102704 [doi]
PST - ppublish
SO  - Proc Inst Mech Eng H. 2022 Aug;236(8):1157-1168. doi: 10.1177/09544119221102704. 
      Epub 2022 Jun 1.