PMID- 35647928
OWN - NLM
STAT- MEDLINE
DCOM- 20230829
LR  - 20230829
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 99
IP  - 9
DP  - 2023
TI  - Mechanistic approach of the therapeutic potential of mesenchymal stem cells on 
      brain damage in irradiated mice: emphasis on anti-inflammatory and anti-apoptotic 
      effects.
PG  - 1463-1472
LID - 10.1080/09553002.2022.2084170 [doi]
AB  - BACKGROUND AND OBJECTIVES: Brain damage which has been induced by radiation 
      generally occurs in radiotherapeutics patients. Stem cell transplantation 
      represents a vital applicant for alleviating neurodegenerative disorders. This 
      work aims at exploring the potential of bone marrow-derived mesenchymal stem 
      cells (BM-MSCs) on brain injury induced by gamma radiation in mice and the possible 
      underlying mechanisms were elucidated. MATERIALS AND METHODS: Mice were allocated 
      into three groups; Group I (Control), Group II (Irradiated control) where mice 
      submitted to 5 Gy of whole-body gamma radiation, Group III (Irradiated + BM-MSCs) 
      where mice were intravenously injected of BM-MSCs at a dose of 10(6) cells/mice 
      24 h following irradiation. Animals were sacrificed 28 d following exposure to gamma 
      radiation. RESULTS: It was observed that BM-MSCs therapy provided a valuable 
      tissue repair as evidenced by a reduction in inflammatory mediators including 
      tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), nuclear factor kappa 
      (NF-kappabeta), phosphorylated NF-kappabeta-p65 (P-NF-kappabeta-p65), interferon-gamma (IFNgamma) and 
      monocyte chemoattractant protein-1 (MCP-1) associated with decreased levels of 
      transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor 
      (VEGF) in brain tissues of irradiated mice. Furthermore, neuronal apoptosis was 
      declined in brain tissues of the BM-MSCs group as remarkable inhibition of 
      caspase-3 and Bax accompanied by elevation of Bcl-2 proteins expression. These 
      results were supported by histopathological investigation. CONCLUSIONS: In 
      conclusion, BM-MSCs could display a vital rule in alleviating brain injury in 
      radio-therapeutic patients.
FAU - Radwan, Rasha R
AU  - Radwan RR
AUID- ORCID: 0000-0001-7344-2123
AD  - Department of Drug Radiation Research, National Center for Radiation Research and 
      Technology, Egyptian Atomic Energy Authority, Nasr City, Egypt.
FAU - Mohamed, Heba A
AU  - Mohamed HA
AUID- ORCID: 0000-0002-6281-6027
AD  - Department of Drug Radiation Research, National Center for Radiation Research and 
      Technology, Egyptian Atomic Energy Authority, Nasr City, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20230223
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Vascular Endothelial Growth Factor A
MH  - *Mesenchymal Stem Cells/metabolism
MH  - Anti-Inflammatory Agents
MH  - *Brain Injuries/etiology/therapy
MH  - Brain/metabolism
OTO - NOTNLM
OT  - brain injury
OT  - mesenchymal stem cell
OT  - neuroinflammation
OT  - neuronal apoptosis
OT  - gamma Irradiation
EDAT- 2022/06/02 06:00
MHDA- 2023/08/29 12:43
CRDT- 2022/06/01 12:05
PHST- 2023/08/29 12:43 [medline]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/01 12:05 [entrez]
AID - 10.1080/09553002.2022.2084170 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2023;99(9):1463-1472. doi: 10.1080/09553002.2022.2084170. Epub 
      2023 Feb 23.