PMID- 35648156
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20220726
IS  - 1420-908X (Electronic)
IS  - 1023-3830 (Linking)
VI  - 71
IP  - 7-8
DP  - 2022 Aug
TI  - The purinergic signalling and inflammation in the pathogenesis and progression of 
      diabetes: key factors and therapeutic targets.
PG  - 759-770
LID - 10.1007/s00011-022-01587-x [doi]
AB  - Type 2 diabetes mellitus (T2DM) is an important chronic disease around the world, 
      and according to the World Health Organization, it is the 9th principal cause of 
      global death. This pathology is characterized by high levels of circulating 
      glucose as a result of insulin resistance, and it is well stated that 
      inflammation related to obesity is directly associated with the development of 
      the disease. The purinergic signalling is involved in both pancreatic 
      destruction, which impairs insulin secretion, and the cytokine production that 
      favors insulin resistance in T2DM. In this review, the purinergic signalling 
      aspects will be discussed, showing the impact of the enzymes, nucleotides, 
      nucleosides, and receptors of this system and the cytokines that result in 
      inflammation, in the development and progression of T2DM, besides, pointing the 
      purinergic receptors as a possible therapeutic approach.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - de Lima, Andre Campos
AU  - de Lima AC
AD  - Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, 
      Chapeco, Brazil.
FAU - Chaves, Lucas Macedo
AU  - Chaves LM
AD  - Medical Course, Federal University of Fronteira Sul, Chapeco, Brazil.
FAU - Prestes, Samantha Nuncio
AU  - Prestes SN
AD  - Medical Course, Federal University of Fronteira Sul, Chapeco, Brazil.
FAU - Manica, Aline
AU  - Manica A
AD  - Health Science Department, Community University of the Region of Chapeco 
      (UNOCHAPECO), Chapeco, SC, Brazil.
FAU - Cardoso, Andreia Machado
AU  - Cardoso AM
AUID- ORCID: 0000-0003-4243-8855
AD  - Graduate Program in Biomedical Sciences, Medical Course, Federal University of 
      Fronteira Sul, Fronteira Sul, Campus Chapeco, Rodovia SC 484 - Km 02, Chapeco, 
      89815-899, Brazil. deiaa.mc@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220601
PL  - Switzerland
TA  - Inflamm Res
JT  - Inflammation research : official journal of the European Histamine Research 
      Society ... [et al.]
JID - 9508160
SB  - IM
MH  - *Diabetes Mellitus, Type 2/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - *Insulin Resistance
MH  - Obesity/pathology
MH  - Signal Transduction
OTO - NOTNLM
OT  - Immune system
OT  - Inflammation
OT  - Purinergic signalling
OT  - T2DM
EDAT- 2022/06/02 06:00
MHDA- 2022/07/27 06:00
CRDT- 2022/06/01 12:14
PHST- 2022/02/23 00:00 [received]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
PHST- 2022/06/01 12:14 [entrez]
AID - 10.1007/s00011-022-01587-x [pii]
AID - 10.1007/s00011-022-01587-x [doi]
PST - ppublish
SO  - Inflamm Res. 2022 Aug;71(7-8):759-770. doi: 10.1007/s00011-022-01587-x. Epub 2022 
      Jun 1.