PMID- 35649224
OWN - NLM
STAT- MEDLINE
DCOM- 20220603
LR  - 20230821
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 68
IP  - 6
DP  - 2022 Jun 1
TI  - Right Ventricular Dysfunction is Associated with Increased Mortality in Patients 
      Requiring Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 
      2019.
PG  - 772-778
LID - 10.1097/MAT.0000000000001666 [doi]
AB  - Respiratory failure caused by severe acute respiratory syndrome coronavirus-2 
      (SARS-CoV-2) is associated with mortality. Patients unresponsive to conventional 
      therapy may benefit from temporary venovenous extracorporeal membrane oxygenation 
      (VV-ECMO). We investigated clinical and echocardiographic characteristics, 
      particularly, right ventricular dysfunction, with survival in patients with 
      respiratory failure caused by SARS-CoV-2. We performed a single-center 
      retrospective cohort study of patients requiring VV-ECMO for respiratory failure 
      from COVID-19 infection between January 2020 and December 2020. Demographics, 
      comorbidities, laboratory parameters, and echocardiographic features of left and 
      right ventricular (LV/RV) function were compared between patients who survived 
      and those who could not be weaned from VV-ECMO. In addition, we evaluated 
      outcomes in a separate population managed with venoarterial extracorporeal 
      membrane oxygenation (VA-ECMO). In total, 10/17 patients failed to wean from 
      VV-ECMO and died in the hospital on average 41.5 +/- 10.9 days post admission. 
      Seven were decannulated (41%) and survived to hospital discharge. There were no 
      significant differences in demographics, comorbidities, and laboratory parameters 
      between groups. Moderate to severe RV dysfunction was significantly more in those 
      who died (8/10, 80%) compared to survivors (0/7, 0%) (p = 0.002). Patients 
      supported with VA-ECMO had superior survival with 5/9 patients (56%) decannulated 
      and discharged. Moderate to severe RV dysfunction is associated with increased 
      mortality in patients with respiratory failure requiring VV-ECMO for COVID-19.
CI  - Copyright (c) ASAIO 2022.
FAU - Maharaj, Valmiki
AU  - Maharaj V
AUID- ORCID: 0000-0003-0442-0021
AD  - From the Department of Medicine, Division of Cardiology, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Alexy, Tamas
AU  - Alexy T
AUID- ORCID: 0000-0001-8381-6299
AD  - From the Department of Medicine, Division of Cardiology, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Agdamag, Arianne C
AU  - Agdamag AC
AUID- ORCID: 0000-0002-2948-039
AD  - From the Department of Medicine, Division of Cardiology, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Kalra, Rajat
AU  - Kalra R
AUID- ORCID: 0000-0002-6293-8104
AD  - From the Department of Medicine, Division of Cardiology, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Nzemenoh, Bellony N
AU  - Nzemenoh BN
AD  - Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
FAU - Charpentier, Victoria
AU  - Charpentier V
AUID- ORCID: 0000-0002-9712-3677
AD  - University of Minnesota, Medical School, Minneapolis, Minnesota.
FAU - Bartos, Jason A
AU  - Bartos JA
AUID- ORCID: 0000-0003-0113-5305
AD  - From the Department of Medicine, Division of Cardiology, University of Minnesota, 
      Minneapolis, Minnesota.
AD  - Center for Resuscitation Medicine, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Brunsvold, Melissa E
AU  - Brunsvold ME
AUID- ORCID: 0000-0003-4044-1591
AD  - Division of Critical Care/Acute Care Surgery, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Yannopoulos, Demetris
AU  - Yannopoulos D
AD  - From the Department of Medicine, Division of Cardiology, University of Minnesota, 
      Minneapolis, Minnesota.
AD  - Center for Resuscitation Medicine, University of Minnesota, Minneapolis, 
      Minnesota.
LA  - eng
PT  - Journal Article
DEP - 20220207
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
CIN - ASAIO J. 2023 Feb 1;69(2):e110-e111. PMID: 35609186
CIN - ASAIO J. 2023 Feb 1;69(2):e109. PMID: 35749753
MH  - *COVID-19/complications/therapy
MH  - Death
MH  - *Extracorporeal Membrane Oxygenation/adverse effects
MH  - Humans
MH  - *Respiratory Insufficiency/etiology/therapy
MH  - Retrospective Studies
MH  - SARS-CoV-2
MH  - *Ventricular Dysfunction, Right/complications/therapy
PMC - PMC9148640
COIS- Disclosure: Jason A. Bartos and Demetris Yannopoulos received philanthropic 
      grants for resuscitation and ECMO research from NIH. The remaining authors have 
      no conflicts of interest to report.
EDAT- 2022/06/02 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/02/07
CRDT- 2022/06/01 16:13
PHST- 2022/06/01 16:13 [entrez]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/02/07 00:00 [pmc-release]
AID - 00002480-202206000-00005 [pii]
AID - 10.1097/MAT.0000000000001666 [doi]
PST - ppublish
SO  - ASAIO J. 2022 Jun 1;68(6):772-778. doi: 10.1097/MAT.0000000000001666. Epub 2022 
      Feb 7.