PMID- 35649441
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20220623
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 303
IP  - Pt 2
DP  - 2022 Sep
TI  - Exposure to BDE-47 and BDE-209 impaired antioxidative defense mechanisms in 
      Brachionus plicatilis.
PG  - 135152
LID - S0045-6535(22)01645-9 [pii]
LID - 10.1016/j.chemosphere.2022.135152 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants (POPs) 
      that pose serious challenges to aquatic animals and environments. Compared with 
      BDE-47 which was one of the most toxic congeners known to date, BDE-209 is less 
      toxic with higher abundance in biotic and abiotic samples. In this study, we have 
      explored the effects of BDE-47 and BDE-209 at different concentrations on the 
      radical oxygen species (ROS) levels and the antioxidant defense system of 
      Brachionus plicatilis. Antioxidant indexes were measured, including total protein 
      content (TSP), the activities of antioxidant enzymes, lipid peroxidation and DNA 
      damage. The results indicated that while low concentrations of PBDEs could 
      activate the antioxidant defense mechanisms, prolonged exposure to higher 
      concentrations of PBDEs could impair the antioxidative capacity of B.plicatilis 
      (P < 0.05). The overwhelming of the B.plicatilis antioxidant defense mechanism 
      led to an accumulation of free radicals, resulting in the overactivation of lipid 
      peroxidation and the increased frequency of DNA damage (P < 0.05). By studying 
      the toxicity of PBDEs and the detoxification mechanism of B.plicatilis, our 
      research has revealed useful indexes for detecting and monitoring the level of 
      BDE-47 and BDE-209 in the future. Altogether, this study holds immense value in 
      the field of ecotoxicology and environmental safety and will aid in the proper 
      management of PBDEs pollution.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Sha, Jingjing
AU  - Sha J
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China.
FAU - Jian, Xiaoyang
AU  - Jian X
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China.
FAU - Yu, Qingyun
AU  - Yu Q
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China.
FAU - Wei, Miao
AU  - Wei M
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China.
FAU - Li, Xiaoyu
AU  - Li X
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China.
FAU - Zhao, Ludan
AU  - Zhao L
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China.
FAU - Qi, Yanping
AU  - Qi Y
AD  - North China Sea Environmental Monitoring Center, State Oceanic Administration, 
      Qingdao, 266033, China; Key Laboratory of Ecological Prewarning and Protection of 
      Bohai Sea, Ministry of Natural Resources, Qingdao, 266033, China. Electronic 
      address: qiyanping01@foxmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220529
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Antioxidants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Defense Mechanisms
MH  - Environmental Monitoring
MH  - *Halogenated Diphenyl Ethers/metabolism
MH  - *Rotifera
OTO - NOTNLM
OT  - Antioxidant enzyme activity
OT  - BDE-209
OT  - BDE-47
OT  - Brachionus plicatilis
OT  - DNA Damages
OT  - Lipid peroxidation
EDAT- 2022/06/02 06:00
MHDA- 2022/06/24 06:00
CRDT- 2022/06/01 19:22
PHST- 2022/03/03 00:00 [received]
PHST- 2022/05/23 00:00 [revised]
PHST- 2022/05/25 00:00 [accepted]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
PHST- 2022/06/01 19:22 [entrez]
AID - S0045-6535(22)01645-9 [pii]
AID - 10.1016/j.chemosphere.2022.135152 [doi]
PST - ppublish
SO  - Chemosphere. 2022 Sep;303(Pt 2):135152. doi: 10.1016/j.chemosphere.2022.135152. 
      Epub 2022 May 29.