PMID- 35649475
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220621
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 622
DP  - 2022 Jun 25
TI  - Controlled release starch-lipid implant for the therapy of severe malaria.
PG  - 121879
LID - S0378-5173(22)00434-3 [pii]
LID - 10.1016/j.ijpharm.2022.121879 [doi]
AB  - Parenteral depot systems can provide a constant release of drugs over a few days 
      to months. Poly-(lactic acid) (PLA) and Poly-(lactide-co-glycolide) (PLGA) are 
      the most commonly used polymers in the production of these systems. Finding 
      alternatives to these polymers is of great importance to avoid certain drawbacks 
      of these polymers (e.g. microacidity) and to increase the selection 
      possibilities. In this study, different types of starch in combination with 
      glycerol monostearate (GMS) were developed and investigated for their 
      physicochemical properties and release characteristics. The noninvasive method of 
      electron paramagnetic resonance (EPR) was used to study the release kinetics and 
      mechanisms of nitroxide model drugs. The studies demonstrated the general 
      suitability of the system composed of high amylose starch and GMS to form a 
      controlled release system. For further characterization of the prepared system, 
      formulations with different proportions of starch and GMS, loaded with the 
      antimalarial agents artesunate or artemether were prepared. The implants were 
      characterized with X-ray powder diffraction (XRPD) and texture analysis. The in 
      vitro release studies demonstrated the sustained release of artemether over 
      6 days from a starch-based implant which matches desired kinetic for the 
      treatment of severe malaria. In summary, a starch-based implant with appropriate 
      mechanical properties was produced that can be a potential candidate for the 
      treatment of severe malaria.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Esfahani, Golbarg
AU  - Esfahani G
AD  - Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 
      Kurt-Mothes-Strasse 3, 06120 Halle (Saale), Germany.
FAU - Hausler, Olaf
AU  - Hausler O
AD  - Roquette Freres, route haute loge, 62080 Lestrem, France.
FAU - Mader, Karsten
AU  - Mader K
AD  - Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 
      Kurt-Mothes-Strasse 3, 06120 Halle (Saale), Germany. Electronic address: 
      karsten.maeder@pharmazie.uni-halle.de.
LA  - eng
PT  - Journal Article
DEP - 20220529
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Lipids)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9005-25-8 (Starch)
RN  - C7D6T3H22J (Artemether)
SB  - IM
MH  - Artemether
MH  - Delayed-Action Preparations
MH  - Humans
MH  - Lactic Acid/chemistry
MH  - Lipids
MH  - *Malaria/drug therapy
MH  - *Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Starch
OTO - NOTNLM
OT  - Artemether
OT  - Artesunate
OT  - Biodegradable
OT  - Controlled release
OT  - Glycerol monostearate
OT  - Starch
EDAT- 2022/06/02 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/06/01 19:23
PHST- 2022/02/16 00:00 [received]
PHST- 2022/05/09 00:00 [revised]
PHST- 2022/05/26 00:00 [accepted]
PHST- 2022/06/02 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/06/01 19:23 [entrez]
AID - S0378-5173(22)00434-3 [pii]
AID - 10.1016/j.ijpharm.2022.121879 [doi]
PST - ppublish
SO  - Int J Pharm. 2022 Jun 25;622:121879. doi: 10.1016/j.ijpharm.2022.121879. Epub 
      2022 May 29.