PMID- 35651328
OWN - NLM
STAT- MEDLINE
DCOM- 20220629
LR  - 20240228
IS  - 1976-670X (Electronic)
IS  - 1976-6696 (Print)
IS  - 1976-6696 (Linking)
VI  - 55
IP  - 6
DP  - 2022 Jun
TI  - Inhibition of ClC-5 suppresses proliferation and induces apoptosis in 
      cholangiocarcinoma cells through the Wnt/beta-catenin signaling pathway.
PG  - 299-304
AB  - Chloride channel-5 (ClC-5), an important branch of the ClC family, is involved in 
      the regulation of the proliferation and cell-fate of a variety of cells, 
      including tumor cells. However, its function in cholangiocarcinoma (CCA) cells 
      remains enigmatic. Here, we discovered that ClC-5 was up-regulated in CCA tissues 
      and CCA cell lines, while ClC-5 silencing inhibited CCA cell proliferation and 
      induced apoptosis. Further mechanism studies revealed that ClC-5 inhibition could 
      inhibit Wnt/beta-catenin signaling activity and further activate the mitochondria 
      apoptotic pathway in CCA cells. Furthermore, rescuing Wnt/beta-catenin signaling 
      activation eliminated the anti-tumor function of ClC-5 knockdown. Together, our 
      research findings illustrated that ClC-5 inhibition plays an anti-tumor role in 
      CCA cells via inhibiting the activity of the Wnt/beta-catenin pathway, which in turn 
      activates the mitochondrial apoptotic pathway. [BMB Reports 2022; 55(6): 
      299-304].
FAU - Shi, Zhe
AU  - Shi Z
AD  - Department of General Surgery, Affiliated Hospital of Hebei Engineering 
      University, Handan 056002, Korea.
FAU - Zhou, Liyuan
AU  - Zhou L
AD  - Department of Gynaecology, Affiliated Hospital of Hebei Engineering University, 
      Handan 056002, Korea.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Nursing, Medical College, Hebei University of Engineering, Handan 
      056002, Korea.
FAU - Jia, Xiaoyan
AU  - Jia X
AD  - Department of General Surgery, Affiliated Hospital of Hebei Engineering 
      University, Handan 056002, Korea.
FAU - Yu, Xiangjun
AU  - Yu X
AD  - Department of General Surgery, Affiliated Hospital of Hebei Engineering 
      University, Handan 056002, Korea.
FAU - An, Xiaohong
AU  - An X
AD  - Department of Hospital Infection-Control, Jize County People's Hospital, Jize 
      057350, China.
FAU - Han, Yanzhen
AU  - Han Y
AD  - Department of General Surgery, Affiliated Hospital of Hebei Engineering 
      University, Handan 056002, China.
LA  - eng
PT  - News
PT  - Retracted Publication
PL  - Korea (South)
TA  - BMB Rep
JT  - BMB reports
JID - 101465334
RN  - 0 (Chloride Channels)
RN  - 0 (beta Catenin)
SB  - IM
RIN - BMB Rep. 2024 Feb;57(2):123. PMID: 38416114
MH  - Apoptosis
MH  - *Bile Duct Neoplasms/pathology
MH  - Bile Ducts, Intrahepatic/metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Chloride Channels/metabolism
MH  - *Cholangiocarcinoma/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Wnt Signaling Pathway/physiology
MH  - beta Catenin/metabolism
PMC - PMC9252889
COIS- CONFLICTS OF INTEREST The authors have no conflicting interests.
EDAT- 2022/06/03 06:00
MHDA- 2022/06/30 06:00
PMCR- 2022/06/30
CRDT- 2022/06/02 02:02
PHST- 2022/03/07 00:00 [received]
PHST- 2022/06/03 06:00 [pubmed]
PHST- 2022/06/30 06:00 [medline]
PHST- 2022/06/02 02:02 [entrez]
PHST- 2022/06/30 00:00 [pmc-release]
AID - 5596 [pii]
AID - bmb-55-6-299 [pii]
AID - 10.5483/BMBRep.2022.55.6.044 [doi]
PST - ppublish
SO  - BMB Rep. 2022 Jun;55(6):299-304. doi: 10.5483/BMBRep.2022.55.6.044.