PMID- 35652602
OWN - NLM
STAT- MEDLINE
DCOM- 20230913
LR  - 20230920
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Print)
IS  - 0033-2917 (Linking)
VI  - 53
IP  - 10
DP  - 2023 Jul
TI  - Attention allocation to negatively-valenced stimuli in PTSD is associated with 
      reward-related neural pathways.
PG  - 4666-4674
LID - 10.1017/S003329172200157X [doi]
AB  - BACKGROUND: In a recent eye-tracking study we found a differential dwell time 
      pattern for negatively-valenced and neutral faces among patients with 
      posttraumatic stress disorder (PTSD), trauma-exposed healthy control (TEHCs), and 
      healthy control (HC) participants. Here, we explored whether these group 
      differences relate to resting-state functional connectivity (rsFC) patterns of 
      brain areas previously linked to both attention processes and PTSD. These 
      encompass the amygdala, dorsal anterior cingulate cortex (dACC), dorsolateral 
      prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), and nucleus 
      accumbens (NAcc). METHODS: Ten minutes magnetic resonance imaging rsFC scans were 
      recorded in 17 PTSD patients, 21 TEHCs, and 16 HCs. Participants then completed a 
      free-viewing eye-tracking task assessing attention allocation outside the 
      scanner. Dwell time on negatively-valenced stimuli (DT%) were assessed relative 
      to functional connectivity in the aforementioned seed regions of interest 
      (amygdala, dACC, dlPFC, vlPFC, and NAcc) to whole-brain voxel-wise rsFC. RESULTS: 
      As previously reported, group differences occurred in attention allocation to 
      negative-valence stimuli, with longer dwell time on negatively valence stimuli in 
      the PTSD and TEHC groups than the HC group. Higher DT% correlated with weaker 
      NAcc-orbitofrontal cortex (OFC) connectivity in patients with PTSD. Conversely, a 
      positive association emerged in the HC group between DT% and NAcc-OFC 
      connectivity. CONCLUSIONS: While exploratory in nature, present findings may 
      suggest that reward-related brain areas are involved in disengaging attention 
      from negative-valenced stimuli, and possibly in regulating ensuing negative 
      emotions.
FAU - Suarez-Jimenez, Benjamin
AU  - Suarez-Jimenez B
AUID- ORCID: 0000-0002-4765-2458
AD  - Department of Neuroscience, The Del Monte Institute for Neuroscience, University 
      of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
FAU - Lazarov, Amit
AU  - Lazarov A
AUID- ORCID: 0000-0002-2811-2739
AD  - School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
AD  - Department of Psychiatry, Columbia University Irving Medical Center, New York, 
      NY, USA.
FAU - Zhu, Xi
AU  - Zhu X
AUID- ORCID: 0000-0002-9724-7231
AD  - Department of Psychiatry, Columbia University Irving Medical Center and New York 
      State Psychiatric Institute, New York, NY, USA.
FAU - Pine, Daniel S
AU  - Pine DS
AUID- ORCID: 0000-0002-4301-9516
AD  - Section on Developmental Affective Neuroscience, National Institute of Mental 
      Health, Bethesda, MD, USA.
FAU - Bar-Haim, Yair
AU  - Bar-Haim Y
AUID- ORCID: 0000-0002-4630-9180
AD  - School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Neria, Yuval
AU  - Neria Y
AD  - Department of Psychiatry, Columbia University Medical Center and New York State 
      Psychiatric Institute, New York, NY, USA.
LA  - eng
GR  - K01 MH122774/MH/NIMH NIH HHS/United States
GR  - R01 MH131532/MH/NIMH NIH HHS/United States
GR  - T32 MH020004/MH/NIMH NIH HHS/United States
GR  - ZIA MH002781/ImNIH/Intramural NIH HHS/United States
GR  - K01 MH118428/MH/NIMH NIH HHS/United States
GR  - R01 MH105355/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220602
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Humans
MH  - *Stress Disorders, Post-Traumatic
MH  - Brain
MH  - Prefrontal Cortex
MH  - Neural Pathways
MH  - Reward
MH  - Magnetic Resonance Imaging/methods
PMC - PMC9715854
MID - NIHMS1841928
OTO - NOTNLM
OT  - Attention allocation
OT  - PTSD
OT  - eye-tracking
OT  - resting-state functional connectivity (rsFC)
OT  - reward functioning
OT  - trauma-exposure
EDAT- 2022/06/03 06:00
MHDA- 2023/09/13 06:41
PMCR- 2023/07/31
CRDT- 2022/06/02 08:44
PHST- 2023/09/13 06:41 [medline]
PHST- 2022/06/03 06:00 [pubmed]
PHST- 2022/06/02 08:44 [entrez]
PHST- 2023/07/31 00:00 [pmc-release]
AID - S003329172200157X [pii]
AID - 10.1017/S003329172200157X [doi]
PST - ppublish
SO  - Psychol Med. 2023 Jul;53(10):4666-4674. doi: 10.1017/S003329172200157X. Epub 2022 
      Jun 2.