PMID- 35653047
OWN - NLM
STAT- MEDLINE
DCOM- 20220804
LR  - 20220804
IS  - 1573-7403 (Electronic)
IS  - 1386-341X (Linking)
VI  - 25
IP  - 4
DP  - 2022 Aug
TI  - HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH 
      deficiency.
PG  - 615-621
LID - 10.1007/s11102-022-01231-1 [doi]
AB  - PURPOSE: Isolated adrenocorticotropic hormone deficiency is a rare disease; 
      however, since immune check point inhibitors (ICIs) have become widely used, many 
      more cases have been reported. In this study, we compared the human leukocyte 
      antigen (HLA) signatures between ICI-induced isolated adrenocorticotropic hormone 
      deficiency (IAD) and idiopathic IAD (IIAD). DESIGN AND METHODS: Clinical features 
      and HLA frequencies were compared among 13 patients with ICI-induced IAD, 8 
      patients with IIAD, and healthy controls. HLA frequencies of healthy controls 
      were adopted from a HLA database of Japanese population. RESULTS: Age and body 
      mass index were higher, while the rate of weight loss was lower, in patients with 
      ICI-induced IAD than in those with IIAD. No HLA alleles had a significantly 
      higher frequency in patients with ICI-induced IAD than in healthy controls, 
      whereas the frequencies of HLA-DRB1*09:01, HLA-DQA1*03:02, and DQB1*03:03 were 
      significantly higher in patients with IIAD than in healthy controls. CONCLUSIONS: 
      ICI-induced IAD and IIAD were different in terms of HLA frequencies. There were 
      no specific HLAs related to ICI-induced IAD, whereas several HLAs in strong 
      linkage disequilibrium were associated with IIAD. This might suggest that the two 
      diseases have different pathological mechanisms. HLAs unique to IIAD may be 
      helpful in predicting its pathophysiology.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Ono, Mayo
AU  - Ono M
AUID- ORCID: 0000-0001-9115-9591
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Fukuda, Izumi
AU  - Fukuda I
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan. i-fukuda@nms.ac.jp.
FAU - Nagao, Mototsugu
AU  - Nagao M
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Tomiyama, Keiko
AU  - Tomiyama K
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Okazaki-Hada, Mikiko
AU  - Okazaki-Hada M
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Shuto, Yuki
AU  - Shuto Y
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Kobayashi, Shunsuke
AU  - Kobayashi S
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Yamaguchi, Yuji
AU  - Yamaguchi Y
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Nagamine, Tomoko
AU  - Nagamine T
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Nakajima, Yasushi
AU  - Nakajima Y
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Inagaki-Tanimura, Kyoko
AU  - Inagaki-Tanimura K
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
FAU - Sugihara, Hitoshi
AU  - Sugihara H
AD  - Department of Endocrinology, Diabetes and Metabolism, Graduate School of 
      Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20220602
PL  - United States
TA  - Pituitary
JT  - Pituitary
JID - 9814578
RN  - 0 (Immune Checkpoint Inhibitors)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - ACTH Deficiency, Isolated
RN  - Adrenocorticotropic hormone deficiency
SB  - IM
MH  - Adrenal Insufficiency
MH  - *Adrenocorticotropic Hormone/deficiency
MH  - Alleles
MH  - Endocrine System Diseases
MH  - Gene Frequency
MH  - Genetic Diseases, Inborn
MH  - Humans
MH  - Hypoglycemia
MH  - *Immune Checkpoint Inhibitors
OTO - NOTNLM
OT  - HLA
OT  - Hypopituitarism
OT  - Immune checkpoint inhibitor
OT  - Isolated ACTH deficiency
EDAT- 2022/06/03 06:00
MHDA- 2022/08/05 06:00
CRDT- 2022/06/02 11:20
PHST- 2022/05/09 00:00 [accepted]
PHST- 2022/06/03 06:00 [pubmed]
PHST- 2022/08/05 06:00 [medline]
PHST- 2022/06/02 11:20 [entrez]
AID - 10.1007/s11102-022-01231-1 [pii]
AID - 10.1007/s11102-022-01231-1 [doi]
PST - ppublish
SO  - Pituitary. 2022 Aug;25(4):615-621. doi: 10.1007/s11102-022-01231-1. Epub 2022 Jun 
      2.