PMID- 35654912
OWN - NLM
STAT- MEDLINE
DCOM- 20220606
LR  - 20231115
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jun 2
TI  - A systematic review and meta-analysis of HLA class II associations in patients 
      with IgG4 autoimmunity.
PG  - 9229
LID - 10.1038/s41598-022-13042-2 [doi]
LID - 9229
AB  - Autoimmune diseases caused by pathogenic IgG4 subclass autoantibodies (IgG4-AID) 
      include diseases like MuSK myasthenia gravis, pemphigus vulgaris or thrombotic 
      thrombocytopenic purpura. Their etiology is still unknown. Polymorphisms in the 
      human leukocyte antigen (HLA) gene locus, particularly in HLA-DRB1, are known 
      genetic susceptibility factors for autoimmune diseases. We hypothesized a similar 
      role for HLA polymorphisms in IgG4-AID and conducted a systematic review and 
      meta-analysis with case-control studies on IgG4-AID based on MOOSE/ HuGENet 
      guidelines. Genotype (G) and allele (A) frequencies of HLA-DQB1*05 (G: OR 3.8; 
      95% CI 2.44-5.9; p < 0.00001; A: OR 2.54; 95% CI 1.82-3.55; p < 0.00001) and 
      HLA-DRB1*14 (G: OR 4.31; 95% CI 2.82-6.59; p < 0.00001; A: OR 4.78; 95% CI 
      3.52-6.49; p < 0.00001) and the HLA-DRB1*14-DQB1*05 haplotype (OR 6.3; 95% CI 
      3.28-12.09; p < 0.00001/OR 4.98; 95% CI 3.8-6.53; p < 0.00001) were increased 
      while HLA-DRB1*13 (G: OR 0.48; 95% CI 0.34-0.68; p < 0.0001; A: OR 0.46; 95% CI 
      0.34-0.62; p < 0.00001) was decreased in IgG4-AID patients. In conclusion, the 
      HLA-DQB1*05, HLA-DRB1*14 alleles and the HLA-DQB1*05-DRB1*14 haplotype could be 
      genetic risk factors that predispose for the production of pathogenic IgG4 
      autoantibodies and the HLA-DRB1*13 allele may protect from IgG4 autoimmunity.
CI  - (c) 2022. The Author(s).
FAU - Panhuber, Anja
AU  - Panhuber A
AD  - Division of Neuropathology and Neurochemistry, Department of Neurology, Medical 
      University of Vienna, Vienna, Austria.
FAU - Lamorte, Giovanni
AU  - Lamorte G
AD  - Division of Neuropathology and Neurochemistry, Department of Neurology, Medical 
      University of Vienna, Vienna, Austria.
FAU - Bruno, Veronica
AU  - Bruno V
AD  - Division of Neuropathology and Neurochemistry, Department of Neurology, Medical 
      University of Vienna, Vienna, Austria.
FAU - Cetin, Hakan
AU  - Cetin H
AD  - Department of Neurology, Medical University of Vienna, Vienna, Austria.
FAU - Bauer, Wolfgang
AU  - Bauer W
AD  - Department of Dermatology, Medical University of Vienna, Vienna, Austria.
FAU - Hoftberger, Romana
AU  - Hoftberger R
AD  - Division of Neuropathology and Neurochemistry, Department of Neurology, Medical 
      University of Vienna, Vienna, Austria.
FAU - Erber, Astrid C
AU  - Erber AC
AD  - Department of Epidemiology, Center for Public Health, Medical University of 
      Vienna, Vienna, Austria.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, UK.
FAU - Frommlet, Florian
AU  - Frommlet F
AD  - Center for Medical Statistics Informatics and Intelligent Systems, Section for 
      Medical Statistics, Medical University of Vienna, Vienna, Austria.
FAU - Koneczny, Inga
AU  - Koneczny I
AUID- ORCID: 0000-0002-0567-021X
AD  - Division of Neuropathology and Neurochemistry, Department of Neurology, Medical 
      University of Vienna, Vienna, Austria. inga.koneczny@meduniwien.ac.at.
LA  - eng
GR  - I 4685/FWF_/Austrian Science Fund FWF/Austria
GR  - T996-B30/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20220602
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Autoantibodies/genetics
MH  - *Autoimmunity/genetics
MH  - Gene Frequency
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Immunoglobulin G/genetics
MH  - *Pemphigus/genetics
PMC - PMC9163138
COIS- The authors declare no competing interests.
EDAT- 2022/06/03 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/06/02
CRDT- 2022/06/02 23:26
PHST- 2021/10/28 00:00 [received]
PHST- 2022/05/13 00:00 [accepted]
PHST- 2022/06/02 23:26 [entrez]
PHST- 2022/06/03 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/06/02 00:00 [pmc-release]
AID - 10.1038/s41598-022-13042-2 [pii]
AID - 13042 [pii]
AID - 10.1038/s41598-022-13042-2 [doi]
PST - epublish
SO  - Sci Rep. 2022 Jun 2;12(1):9229. doi: 10.1038/s41598-022-13042-2.