PMID- 35655764
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2251-7251 (Print)
IS  - 2251-726X (Electronic)
IS  - 2251-7251 (Linking)
VI  - 34
IP  - 121
DP  - 2022 Mar
TI  - Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke's 
      Edema and Those with Laryngeal Cancer.
PG  - 95-105
LID - 10.22038/IJORL.2022.52799.2797 [doi]
AB  - INTRODUCTION: The present study aimed to assess human leukocyte antigen (HLA) 
      typing differences between smokers with Reinke's edema and those with laryngeal 
      squamous cell carcinoma (SCC). MATERIALS AND METHODS: The HLA class I, II alleles 
      were examined in 76 unrelated Iranian patients using low-resolution polymerase 
      chain reaction with the sequence-specific primer (PCR-SSP) method. RESULTS: The 
      frequency of the HLA-A*36 allele and HLA-B*35 was significantly higher in 
      patients with SCC. The frequency of HLA-DRB1*01 alleles in Reinke's edema was 
      significantly higher, as compared to that in others. In the volunteer group, 
      HLA-DRB1*13 and HLA-DRB1*15 were significantly higher. CONCLUSIONS: As evidenced 
      by the obtained results, HLA-A*36 was significantly higher in SCC, as compared to 
      that in volunteers and Reinke's edema patients. It can be concluded that being 
      positive for HLA-A*36 increases the chance of SCC by three times. This result 
      should be further investigated in cohort studies conducted on larger samples. 
      Furthermore, HLA-A*24 was significantly higher in the volunteer group, as 
      compared to that in other groups. The HLADRB1*01 was remarkably higher in 
      Reinke's edema, as compared to that in SCC.
FAU - Izadi, Farzad
AU  - Izadi F
AD  - ENT and Head and Neck Research Center, the five Senses Health Institute, School 
      of Medicine, Iran University of Medical Sciences.
FAU - Ahmadi, Aslan
AU  - Ahmadi A
AD  - ENT and Head and Neck Research Center, the five Senses Health Institute, School 
      of Medicine, Iran University of Medical Sciences.
FAU - Hosseinzadeh, Farideh
AU  - Hosseinzadeh F
AD  - ENT and Head and Neck Research Center, the five Senses Health Institute, School 
      of Medicine, Iran University of Medical Sciences.
FAU - Mirsalehi, Marjan
AU  - Mirsalehi M
AD  - ENT and Head and Neck Research Center, the five Senses Health Institute, School 
      of Medicine, Iran University of Medical Sciences.
FAU - Shakiba, Yadollah
AU  - Shakiba Y
AD  - Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Bahar, Mohammad Ali
AU  - Bahar MA
AD  - Department of Immunology, Iran University of Medical Sciences, Tehran, Iran.
FAU - Balali, Maryam
AU  - Balali M
AD  - ENT and Head and Neck Research Center, the five Senses Health Institute, School 
      of Medicine, Iran University of Medical Sciences.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Otorhinolaryngol
JT  - Iranian journal of otorhinolaryngology
JID - 101577699
PMC - PMC9119329
OTO - NOTNLM
OT  - Human leukocyte antigen
OT  - Hypertrophic edema
OT  - Iranian
OT  - Polymerase chain reaction sequence-specific primers
OT  - Reinke's edema
EDAT- 2022/06/04 06:00
MHDA- 2022/06/04 06:01
PMCR- 2022/03/01
CRDT- 2022/06/03 02:17
PHST- 2020/10/29 00:00 [received]
PHST- 2022/02/06 00:00 [accepted]
PHST- 2022/06/03 02:17 [entrez]
PHST- 2022/06/04 06:00 [pubmed]
PHST- 2022/06/04 06:01 [medline]
PHST- 2022/03/01 00:00 [pmc-release]
AID - 10.22038/IJORL.2022.52799.2797 [doi]
PST - ppublish
SO  - Iran J Otorhinolaryngol. 2022 Mar;34(121):95-105. doi: 
      10.22038/IJORL.2022.52799.2797.