PMID- 35656542
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2673-3080 (Electronic)
IS  - 2673-3080 (Linking)
VI  - 4
DP  - 2022
TI  - Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses.
PG  - 909307
LID - 10.3389/ftox.2022.909307 [doi]
LID - 909307
AB  - Living in an industrialized era, we are exposed to man-made chemicals including 
      persistent organic pollutants (POPs). Previous studies have shown associations of 
      POP exposure with adverse outcomes in humans, wildlife, and the environment, 
      making it a global concern. Exposure during sensitive windows of susceptibility 
      such as fetal development is of particular concern because of the potential 
      increased risk of developing diseases in childhood and adulthood. However, there 
      are limited studies on the sexual dimorphism of POP accumulation during the 
      prenatal period. In this mini-review, we focus on differences in POP 
      concentrations in the placenta and fetal tissues between males and females. We 
      also show the sexually dimorphic adverse outcomes of prenatal exposure to POPs. 
      Overall, our summary shows that males may accumulate higher concentrations of 
      POPs in the placenta and fetal tissues compared to females, although studies are 
      sparse and inconsistent. In addition, there are differences in adverse health 
      outcomes associated to prenatal POP exposure according to sex. Hence, we highly 
      urge researchers investigating the health effects of POP exposure to consider 
      sexual dimorphism in their studies.
CI  - Copyright (c) 2022 Bjorvang and Mamsen.
FAU - Bjorvang, Richelle D
AU  - Bjorvang RD
AD  - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
AD  - Division of Obstetrics and Gynecology, Department of Clinical Science, 
      Intervention and Technology, Karolinska Institutet and Karolinska University 
      Hospital Huddinge, Stockholm, Sweden.
FAU - Mamsen, Linn Salto
AU  - Mamsen LS
AD  - Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children 
      and Reproduction, University Hospital of Copenhagen, University of Copenhagen, 
      Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220517
PL  - Switzerland
TA  - Front Toxicol
JT  - Frontiers in toxicology
JID - 101777990
PMC - PMC9152108
OTO - NOTNLM
OT  - OCP
OT  - PBDE
OT  - PCB
OT  - PFAS
OT  - chemical transfer
OT  - human fetal exposure
OT  - persisting organic pollutants
OT  - sex differences
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/04 06:00
MHDA- 2022/06/04 06:01
PMCR- 2022/05/17
CRDT- 2022/06/03 02:30
PHST- 2022/03/31 00:00 [received]
PHST- 2022/04/29 00:00 [accepted]
PHST- 2022/06/03 02:30 [entrez]
PHST- 2022/06/04 06:00 [pubmed]
PHST- 2022/06/04 06:01 [medline]
PHST- 2022/05/17 00:00 [pmc-release]
AID - 909307 [pii]
AID - 10.3389/ftox.2022.909307 [doi]
PST - epublish
SO  - Front Toxicol. 2022 May 17;4:909307. doi: 10.3389/ftox.2022.909307. eCollection 
      2022.