PMID- 35657279
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20221215
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 44
IP  - 6
DP  - 2022 Dec
TI  - N-acetylcysteine decreases lung inflammation and fibrosis by modulating ROS and 
      Nrf2 in mice model exposed to particulate matter.
PG  - 832-837
LID - 10.1080/08923973.2022.2086138 [doi]
AB  - Background and Objectives: Air pollutants can induce and incite airway diseases 
      such as asthma. N-acetylcysteine (NAC) affects signaling pathways involved in 
      apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, 
      and the inflammatory response. However, it is not known how NAC change 
      redox-regulated gene expression in asthma mouse model exposed to particulate 
      matter (PM). To investigate the effects of NAC on asthma mice exposed to PM 
      through Reactive oxygen species (ROS), nuclear factor erythroid 2-related factor 
      2 (Nrf2), and mucin 5 (Muc5).Methods: To investigate the effects of NAC 
      (100 mg/kg) on redox-regulated gene expression and lung fibrosis in a mouse model 
      of asthma exposed to PM. A mice model of asthma induced by ovalbumin (OVA) or OVA 
      plus titanium dioxide (OVA + TiO(2)) was established using wild-type BALB/c 
      female mice, and the levels of Nrf2 and mucin 5AC (Muc5ac) proteins following NAC 
      treatment were examined by Western blotting and immunostaining. In addition, the 
      protein levels of ROS were checked.Results: Airway hyperresponsiveness and 
      inflammation, goblet cell hyperplasia, and lung fibrosis were higher in OVA, 
      OVA + TiO(2) mice than in control mice. NAC diminished OVA + TiO(2)-induced 
      airway hyperresponsiveness and inflammation, goblet cell hyperplasia, and lung 
      fibrosis. Levels of ROS, Nrf2, and Muc5ac protein were higher in lung tissue from 
      OVA + TiO(2) mice than that from control mice and were decreased by treatment 
      with NAC.Conclusions: NAC reduce airway inflammation and responsiveness, goblet 
      cell hyperplasia, and lung fibrosis by modulating ROS and Nrf2.
FAU - Choi, Seon-Muk
AU  - Choi SM
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
FAU - Lee, Pureun-Haneul
AU  - Lee PH
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
FAU - An, Min-Hyeok
AU  - An MH
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
FAU - Yun-Gi, Lee
AU  - Yun-Gi L
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
FAU - Park, Shinhee
AU  - Park S
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
FAU - Baek, Ae Rin
AU  - Baek AR
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
FAU - Jang, An-Soo
AU  - Jang AS
AD  - Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 
      Bucheon, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20220711
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - WYQ7N0BPYC (Acetylcysteine)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Female
MH  - Mice
MH  - Animals
MH  - Acetylcysteine/pharmacology
MH  - Particulate Matter/toxicity
MH  - *Pulmonary Fibrosis/chemically induced/drug therapy
MH  - Hyperplasia
MH  - *Pneumonia/chemically induced/drug therapy
MH  - *Respiratory Hypersensitivity
OTO - NOTNLM
OT  - Asthma
OT  - N-acetylcysteine
OT  - Nrf2
OT  - PM
OT  - ROS
EDAT- 2022/06/04 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/06/03 09:52
PHST- 2022/06/04 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/06/03 09:52 [entrez]
AID - 10.1080/08923973.2022.2086138 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2022 Dec;44(6):832-837. doi: 
      10.1080/08923973.2022.2086138. Epub 2022 Jul 11.