PMID- 35657310
OWN - NLM
STAT- MEDLINE
DCOM- 20230317
LR  - 20230317
IS  - 1678-9741 (Electronic)
IS  - 0102-7638 (Print)
IS  - 0102-7638 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Feb 10
TI  - Reduced Angiopoietin Factor 2 Levels Are Correlated with Better Cardiac Function 
      and Prognosis in Valvular Heart Disease.
PG  - 104-109
LID - 10.21470/1678-9741-2021-0364 [doi]
AB  - INTRODUCTION: There are few circulating biomarkers for valvular heart disease. 
      Angiopoietin (Ang) 1, Ang2, and vascular endothelial growth factor are important 
      inflammation-associated cytokines. The aim of this study was to investigate the 
      clinical significance and association of Ang1, Ang2, and vascular endothelial 
      growth factor in valvular heart disease. METHODS: This is a retrospective study; 
      a total of 62 individuals (valvular heart disease patients [n=42] and healthy 
      controls [n=20]) were included. Plasma levels of Ang1, Ang2, and vascular 
      endothelial growth factor were detected by enzyme-linked immunosorbent assays. We 
      retrospectively collected the baseline characteristics and short-term outcomes; 
      logistic regression was performed to identify predictor for short-term mortality. 
      RESULTS: Ang2 was significantly decreased in the valvular heart disease group 
      compared with the healthy control group (P=0.023), while no significant 
      difference was observed in the Ang1 and vascular endothelial growth factor 
      levels. The Ang2 level of New York Heart Association (NYHA) I/II patients - but 
      not NYHA III/IV patients - was significantly decreased compared with that of 
      healthy control individuals (NYHA I/II: P=0.017; NYHA III/IV: P=0.485). 
      Univariable logistic regression analysis indicated that Ang2 was a significant 
      independent predictor for short-term mortality (odds ratio 18.75, P=0.033, 95% 
      confidence interval 8.08-102.33). Ang1 was negatively correlated with Ang2 
      (P=0.032, Pearson's correlation coefficient =-0.317) and was positively 
      correlated with vascular endothelial growth factor (P=0.019, Pearson's 
      correlation coefficient = 0.359). CONCLUSION: Ang2 might serve as a therapeutic 
      and prognostic target for valvular heart disease.
FAU - Hou, Jian
AU  - Hou J
AD  - Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong Province, People's Republic of China.
AD  - NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, 
      Guangdong Province, People's Republic of China.
FAU - Huang, Xiaolin
AU  - Huang X
AD  - Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong Province, People's Republic of China.
AD  - NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, 
      Guangdong Province, People's Republic of China.
FAU - Shang, Liqun
AU  - Shang L
AD  - Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong Province, People's Republic of China.
AD  - NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, 
      Guangdong Province, People's Republic of China.
FAU - Chen, Guangxian
AU  - Chen G
AD  - Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong Province, People's Republic of China.
AD  - NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, 
      Guangdong Province, People's Republic of China.
FAU - Wu, Huawei
AU  - Wu H
AD  - Department of Neurobiology, Physiology and Behavior, College of Biological 
      Sciences, University of California, Davis, California, United States of America.
FAU - Wu, Zhongkai
AU  - Wu Z
AUID- ORCID: 0000-0003-1184-1182
AD  - Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong Province, People's Republic of China.
AD  - NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, 
      Guangdong Province, People's Republic of China.
FAU - Huang, Suiqing
AU  - Huang S
AD  - Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong Province, People's Republic of China.
AD  - NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, 
      Guangdong Province, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230210
PL  - Brazil
TA  - Braz J Cardiovasc Surg
JT  - Brazilian journal of cardiovascular surgery
JID - 101677045
RN  - 0 (Angiopoietins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - 0 (VPS51 protein, human)
SB  - IM
MH  - Humans
MH  - Angiopoietins
MH  - *Heart Valve Diseases
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
PMC - PMC10010708
OTO - NOTNLM
OT  - Angiopoietin 1
OT  - Angiopoietin 2
OT  - Cytokines
OT  - Heart Valve Diseases
OT  - Inflammation
OT  - Valvular Heart Disease
COIS- No conflict of interest.
EDAT- 2022/06/04 06:00
MHDA- 2023/03/15 06:00
PMCR- 2023/01/01
CRDT- 2022/06/03 10:22
PHST- 2022/06/04 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2022/06/03 10:22 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.21470/1678-9741-2021-0364 [doi]
PST - epublish
SO  - Braz J Cardiovasc Surg. 2023 Feb 10;38(1):104-109. doi: 
      10.21470/1678-9741-2021-0364.