PMID- 35658323
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220608
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 57
IP  - 5
DP  - 2022 May 25
TI  - [Clinical characteristics and pregnancy outcomes of pregnant women with left 
      ventricular non-compaction].
PG  - 332-338
LID - 10.3760/cma.j.cn112141-20220126-00049 [doi]
AB  - Objective: To investigate the clinical characteristics and pregnancy outcomes in 
      pregnant women with left ventricular non-compaction (LVNC). Methods: The clinical 
      data of seven pregnant women with LVNC from January 2011 to December 2021 in 
      Beijing Anzhen Hospital,Capital Medical University were retrospectively analyzed, 
      including age, gestational age of symptom first occured, LVNC history, clinical 
      symptoms, New York Heart Association (NYHA) cardiac function class, 
      echocardiography, blood brain natriuretic peptide (BNP), treatment and the 
      maternal and fetal outcomes. Results: Five cases were diagnosed before pregnancy, 
      of which there were three women with medication; one case diagnosed in the month 
      of pregnancy; one case diagnosed at 36 weeks of gestation. NYHA cardiac function 
      was grade Ⅰ in four cases and grade Ⅱ in three cases before or during the first 
      trimester of pregnancy. Of the five pregnant women who underwent 
      echocardiography, there were one case of left ventricular insufficiency, three 
      cases of mild left ventricular dysfunction and one case of normal left 
      ventricular function before or during the first trimester of pregnancy. Of the 
      five pregnant women to the second and third trimester of pregnancy, there were 
      one case of grade Ⅳ, one case of grade Ⅲ, two cases of grade Ⅱ-Ⅲ and one case of 
      grade Ⅱ in NYHA class ; three cases of left ventricular insufficiency, two cases 
      of normal left ventricular function by echocardiography four cases had cardiac 
      symptoms at 15-24 weeks of gestation and were treated with medication. In four 
      cases, blood BNP increased to 214-1 197 ng/L during pregnancy, and were 89-106 
      ng/L after termination of pregnancy. There were 4 cases with arrhythmia. 
      Indications for termination of pregnancy: LVNC complicated with heart failure in 
      two cases, LVNC complicated with decreased cardiac function and threatened 
      preterm birth in one case, complicated with pregnancy at full term in two cases, 
      LVNC complicated with severe pulmonary hypertension in one case, and left 
      ventricular dysfunction in one case. Cesarean section in four cases in the 
      third-trimester, in one case in the second-trimester, and forceps curettage in 
      two cases were taken. Two full-term infants,two preterm infants were born without 
      LVNC. Conclusions: Women diagnosed with LVNC and low left ventricular ejection 
      fraction before pregnancy are more prone to decreased cardiac function during 
      pregnancy. Carrying out pregnancy risk assessment and strengthening the 
      multi-disciplinary team management of high risk factors in pregnancy are 
      conducive to achieve good pregnancy outcomes.
FAU - Wang, H Y
AU  - Wang HY
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, 
      Beijing 100029, China.
FAU - Bao, Z L
AU  - Bao ZL
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, 
      Beijing 100029, China.
FAU - Yang, D
AU  - Yang D
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, 
      Beijing 100029, China.
FAU - Li, Y N
AU  - Li YN
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, 
      Beijing 100029, China.
FAU - Bu, L
AU  - Bu L
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, 
      Beijing 100029, China.
FAU - Ding, W W
AU  - Ding WW
AD  - Pediatric Cardiology Center, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, China.
FAU - Zhang, J
AU  - Zhang J
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, 
      Beijing 100029, China.
LA  - chi
GR  - 20190542/Medical Service and Security Capacity Improvement Project of Beijing 
      Municipal Health Commission/
PT  - Journal Article
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
SB  - IM
MH  - Cesarean Section
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Pregnancy
MH  - *Pregnancy Complications, Cardiovascular/diagnosis/therapy
MH  - Pregnancy Outcome
MH  - Pregnant Women
MH  - *Premature Birth
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - *Ventricular Dysfunction, Left
MH  - Ventricular Function, Left
EDAT- 2022/06/07 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/06/06 01:24
PHST- 2022/06/06 01:24 [entrez]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
AID - 10.3760/cma.j.cn112141-20220126-00049 [doi]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2022 May 25;57(5):332-338. doi: 
      10.3760/cma.j.cn112141-20220126-00049.