PMID- 35660542
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20230124
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 364
IP  - 5
DP  - 2022 Nov
TI  - Estimated glomerular filtration rate derived from different formulas and 
      prognosis in acute coronary syndrome: Findings from the improving care for 
      cardiovascular disease in China-acute coronary syndrome project.
PG  - 565-574
LID - S0002-9629(22)00149-5 [pii]
LID - 10.1016/j.amjms.2021.10.034 [doi]
AB  - BACKGROUND: The optimal formula for the estimation of glomerular filtration rate 
      (GFR) in patients with acute coronary syndrome (ACS) in terms of predicting 
      in-hospital mortality and adverse events remains unclear. METHODS: A nationwide 
      registry study, Improving CCC (Care for Cardiovascular Disease in China) ACS 
      project, was launched in 2014 as a collaborative study of the American Heart 
      Association and Chinese Society of Cardiology. The Cockcroft-Gault, modification 
      of diet in renal disease (MDRD) formula for Chinese (C-MDRD), Mayo, and Chronic 
      Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas were used to 
      calculate estimated GFR in 61,545 ACS patients (38,734 with ST-segment elevation 
      myocardial infarction [STEMI] and 22,811 with non-ST-segment-elevation ACS 
      [NSTE-ACS]). RESULTS: Prevalence of moderate to severe renal dysfunction was 
      inconsistent among four formulas, ranging from 11.6% to 22.4% in NSTE-ACS and 
      from 8.3% to 16.8% in STEMI, respectively. The in-hospital mortality rate in 
      patients with ACS was inversely associated with estimated GFR. In STEMI, the 
      Mayo-derived eGFR exhibited the highest predictive power for in-hospital death 
      compared with the Cockcroft-Gault-derived eGFR (area under the curve [AUC]: 0.782 
      vs. 0.768, p=0.004), C-MDRD-derived eGFR (AUC: 0.782 vs. 0.740, p<0.001) and 
      CKD-EPI-derived eGFR (AUC: 0.782 vs. 0.767, p<0.001). In NSTE-ACS, the 
      Mayo-derived eGFR exhibited a similar predictive value with the Cockcroft-Gault 
      (AUC: 0.781 vs. 0.787, p>0.05) and CKD-EPI-derived eGFR (AUC: 0.781 vs. 0.784, 
      p>0.05). CONCLUSIONS: The Mayo formula was superior to Cockcroft-Gault, C-MDRD, 
      and CKD-EPI formulas for predicting in-hospital mortality in ACS patients, 
      especially for STEMI. The Mayo-derived eGFR may serve as a risk-stratification 
      tool for in-hospital adverse events in ACS patients. CLINICAL TRIAL REGISTRATION: 
      URL: http://www. CLINICALTRIALS: gov. Unique identifier: NCT02306616.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Lin, Ying-Wen
AU  - Lin YW
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China; Shantou University Medical College, Shantou 515000, 
      China.
FAU - Huang, Jie-Leng
AU  - Huang JL
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China; Southern Medical University, Guangzhou 510515, China.
FAU - Wei, Xue-Biao
AU  - Wei XB
AD  - Southern Medical University, Guangzhou 510515, China; Department of Critical Care 
      Medicine, Guangdong Geriatrics Institute, Guangdong Provincial People's Hospital, 
      Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Jiang, Mei
AU  - Jiang M
AD  - Southern Medical University, Guangzhou 510515, China; Department of Critical Care 
      Medicine, Guangdong Geriatrics Institute, Guangdong Provincial People's Hospital, 
      Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Ran, Peng
AU  - Ran P
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China.
FAU - Qiu, Jia
AU  - Qiu J
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China.
FAU - Zhong, Qi
AU  - Zhong Q
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China.
FAU - Zhou, Ying-Ling
AU  - Zhou YL
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China.
FAU - Chen, Ji-Yan
AU  - Chen JY
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China. Electronic address: gdchenjiyan@163.com.
FAU - Yu, Dan-Qing
AU  - Yu DQ
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      Guangdong 510080, China. Electronic address: gdydq100@126.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT02306616
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220602
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Humans
MH  - Glomerular Filtration Rate
MH  - *Acute Coronary Syndrome/diagnosis/epidemiology/therapy
MH  - *Cardiovascular Diseases/complications
MH  - *ST Elevation Myocardial Infarction/complications
MH  - Hospital Mortality
MH  - Quality Improvement
MH  - *Renal Insufficiency, Chronic/epidemiology/therapy/complications
MH  - Prognosis
MH  - Creatinine
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Acute myocardial infarction
OT  - Glomerular filtration rate
OT  - Predictors
COIS- Declaration of Competing Interests The authors declare that they have no 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/06/07 06:00
MHDA- 2022/10/25 06:00
CRDT- 2022/06/06 11:40
PHST- 2020/10/03 00:00 [received]
PHST- 2021/06/02 00:00 [revised]
PHST- 2021/10/21 00:00 [accepted]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/06/06 11:40 [entrez]
AID - S0002-9629(22)00149-5 [pii]
AID - 10.1016/j.amjms.2021.10.034 [doi]
PST - ppublish
SO  - Am J Med Sci. 2022 Nov;364(5):565-574. doi: 10.1016/j.amjms.2021.10.034. Epub 
      2022 Jun 2.