PMID- 35662154
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220608
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 63
IP  - 5
DP  - 2022
TI  - [HLA-haploidentical peripheral blood stem cell transplantation with 
      post-transplantation cyclophosphamide for adult T-cell leukemia].
PG  - 333-340
LID - 10.11406/rinketsu.63.333 [doi]
AB  - Recently, allogeneic peripheral blood stem cell transplantation from human 
      leukocyte antigen (HLA)-haploidentical donors using post-transplantation 
      cyclophosphamide (PTCY-haploPBSCT) has become available in clinical practice. 
      However, the efficacy of PTCY in adult T-cell leukemia (ATL) is not fully 
      established yet. In this study, we retrospectively examined data of seven 
      patients who underwent PTCY-haploPBSCT. The overall survival rate at 100 days 
      after transplantation was 85.7%, and the 1-year overall survival rate was 68.6%. 
      The cumulative incidence of relapse at 1 year was 31.4%, whereas the 1-year 
      nonrelapse mortality was 17.1%. The cumulative incidence of grade III-IV acute 
      graft-versus-host disease (GVHD) on day 100 was 14.3%, and the incidence of 
      chronic GVHD at 1 year was 33.3%. These results suggest that PTCY-haploPBSCT can 
      be a viable option even in patients with ATL. Further accumulation of knowledge 
      and improvement of transplantation outcomes are warranted in the future.
FAU - Ishii, Keitaro
AU  - Ishii K
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Okamoto, Sho
AU  - Okamoto S
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Fujita, Mai
AU  - Fujita M
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Sugihara, Ayano
AU  - Sugihara A
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Nagaie, Toshiaki
AU  - Nagaie T
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Nishioka, Atsujiro
AU  - Nishioka A
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Kamachi, Kazuharu
AU  - Kamachi K
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Itamura, Hidekazu
AU  - Itamura H
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Katsuya, Hiroo
AU  - Katsuya H
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Yoshimura, Mariko
AU  - Yoshimura M
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Ureshino, Hiroshi
AU  - Ureshino H
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Ando, Toshihiko
AU  - Ando T
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
FAU - Kubota, Yasushi
AU  - Kubota Y
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
AD  - Department of Transfusion Medicine, Saga University Hospital.
AD  - Department of Transfusion Medicine and Cell Therapy, Saitama Medical Center, 
      Saitama Medical University.
FAU - Kimura, Shinya
AU  - Kimura S
AD  - Division of Hematology, Respiratory Medicine and Oncology, Department of Internal 
      Medicine, Faculty of Medicine, Saga University.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (HLA Antigens)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - Cyclophosphamide/therapeutic use
MH  - *Graft vs Host Disease
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Leukemia-Lymphoma, Adult T-Cell/therapy
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - Retrospective Studies
MH  - Transplantation Conditioning
OTO - NOTNLM
OT  - Adult T-cell leukemia
OT  - HLA-haploidentical stem cell transplantation
OT  - Post-transplantation cyclophosphamide
EDAT- 2022/06/07 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/06/06 13:17
PHST- 2022/06/06 13:17 [entrez]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
AID - 10.11406/rinketsu.63.333 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2022;63(5):333-340. doi: 10.11406/rinketsu.63.333.