PMID- 35663208
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 0019-5049 (Print)
IS  - 0976-2817 (Electronic)
IS  - 0019-5049 (Linking)
VI  - 66
IP  - 4
DP  - 2022 Apr
TI  - Comparison of elevated cardiac troponin I with SAPS-II and APACHE-II score in 
      predicting outcome of severe intoxications.
PG  - 248-254
LID - 10.4103/ija.ija_465_21 [doi]
AB  - BACKGROUND AND AIMS: To date, different methods have been invented to 
      risk-stratify critically ill patients, however, there is a paucity of information 
      regarding assessing the severity of poisonings. This study was designed to 
      determine the comparative efficacy of Simplified Acute Physiology Score-II 
      (SAPS-II) and Acute Physiology and Chronic Health Evaluation-II (APACHE-II)score 
      with cardiac troponin I (cTnI) in predicting severe intoxication outcomes. 
      METHODS: This was a prospective study conducted on patients who fulfilled defined 
      severe intoxication criteria necessitating intensive care unit (ICU) admission 
      over a period of 6 months. SAPS-II and APACHE-II scores were calculated and cTnI 
      concentrations were measured. These indicators were compared to determine which 
      has the better ability to prognosticate mortality and complications. RESULTS: A 
      total of 55 cases (median age, 35 [24-49] years) were enroled. Eight patients 
      (14.5%) died. Mean SAPS-II, median APACHE-II score and median cTnI concentrations 
      were 32.05 +/- 11.24, 13 [10-17] and 0.008 [0.002-0.300] ng/ml, respectively, which 
      were significantly different between the survivors and non-survivors. Receiver 
      operating characteristics curve results of SAPS-II, APACHE-II score and cTnI 
      concentrations in predicting mortality were 0.945, 0.932 and 0.763 and in 
      predicting complications were 0.779, 0.739 and 0.727, respectively. High cTnI 
      concentration (>0.37 ng/ml) correlated with soft clinical outcomes, including 
      length of ventilatory support, length of ICU stay and length of hospital stay 
      (LOS) (r: 0.928, 0.881 and 0.735 respectively; all P < 0.001). CONCLUSION: 
      SAPS-II scores were superior in predicting death and complications, while cTnI 
      correlated more closely with soft clinical outcomes, such as the length of 
      ventilator support, length of ICU stay or LOS.
CI  - Copyright: (c) 2022 Indian Journal of Anaesthesia.
FAU - Mirakbari, Seyed Mostafa
AU  - Mirakbari SM
AD  - Department of Clinical Toxicology, Clinical Research Development Unit, Bu Ali 
      Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
FAU - Kazemifar, Amir Mohammad
AU  - Kazemifar AM
AD  - Department of Clinical Toxicology, Clinical Research Development Unit, Bu Ali 
      Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
FAU - Namdar, Peyman
AU  - Namdar P
AD  - Department of Emergency Medicine, Clinical Research Development Unit, Bu Ali 
      Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
FAU - Seddighi, Mahyar
AU  - Seddighi M
AD  - Department of Anaesthesiology, Clinical Research Development Unit, Bu Ali 
      Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
FAU - Allami, Abbas
AU  - Allami A
AD  - Department of Infectious Diseases, Clinical Research Development Unit, Bu Ali 
      Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
FAU - Barikani, Ameneh
AU  - Barikani A
AD  - Department of Community Medicine, Clinical Research Development Unit, Bu Ali 
      Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220420
PL  - India
TA  - Indian J Anaesth
JT  - Indian journal of anaesthesia
JID - 0013243
PMC - PMC9159406
OTO - NOTNLM
OT  - APACHE
OT  - mortality
OT  - poisoning
OT  - simplified acute physiology score
OT  - troponin
COIS- There are no conflicts of interest.
EDAT- 2022/06/07 06:00
MHDA- 2022/06/07 06:01
PMCR- 2022/04/01
CRDT- 2022/06/06 13:54
PHST- 2021/05/28 00:00 [received]
PHST- 2021/12/03 00:00 [revised]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/06/06 13:54 [entrez]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/06/07 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - IJA-66-248 [pii]
AID - 10.4103/ija.ija_465_21 [doi]
PST - ppublish
SO  - Indian J Anaesth. 2022 Apr;66(4):248-254. doi: 10.4103/ija.ija_465_21. Epub 2022 
      Apr 20.