PMID- 35663772
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2690-442X (Electronic)
IS  - 2690-442X (Linking)
VI  - 1
IP  - 4
DP  - 2021 Dec
TI  - CD8alphaalpha(+)T cells exert a pro-inflammatory role in patients with psoriasis.
PG  - e64
LID - 10.1002/ski2.64 [doi]
LID - e64
AB  - BACKGROUND: Psoriasis is a common chronic inflammatory disease caused by 
      excessive activation of CD4(+)T cells, including Th17, Th1 and Th22. The role of 
      CD8(+)T cells in psoriasis pathogenesis remains poorly understood. AIM: To 
      identify the phenotype of CD8(+)T cells in patients with psoriasis and to 
      investigate its role in the formation of lesions. METHODS: The phenotype of 
      CD8(+)T cells in psoriatic lesions was detected by immunofluorescence staining. 
      Flow cytometry was performed to detect their phenotype in peripheral blood. 
      Thereafter, coculture of CD8alphaalpha(+)T cells with autogenous CD4(+)T cells was 
      performed to investigate the function of CD8alphaalpha(+)T cells in patients with 
      psoriasis. Finally, pro-inflammatory factors produced by CD8alphaalpha(+)T cells were 
      examined by immunofluorescence staining and flow cytometry. RESULTS: Compared to 
      the CD8alphabeta(+)T cells, CD8alphaalpha(+)T cell infiltration in psoriatic lesions markedly 
      increased. Moreover, epidermal CD8alphaalpha(+)T cells exhibited tissue-resident memory T 
      cells (T(RM)) phenotypes and dermal CD8alphaalpha(+)T cells exhibited effector memory 
      (T(EM)) phenotypes in psoriatic lesions. Additionally, we found that CD8alphaalpha(+)T 
      cells from patients with psoriasis did not express the markers of regulatory T 
      cells and could promote the proliferation of CD4(+)T effector cells and produce 
      interleukin-17 and interferon-gamma. CONCLUSIONS: Our findings demonstrate that 
      CD8alphaalpha(+)T cells contribute to the pathogenesis of psoriasis by producing 
      pro-inflammatory factors.
CI  - (c) 2021 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on 
      behalf of British Association of Dermatologists.
FAU - Zhang, Y Y
AU  - Zhang YY
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Lin, Y T
AU  - Lin YT
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Wang, L
AU  - Wang L
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Sun, X W
AU  - Sun XW
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Dang, E L
AU  - Dang EL
AUID- ORCID: 0000-0003-4761-6673
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Xue, K
AU  - Xue K
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Zhang, W G
AU  - Zhang WG
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Zhang, K M
AU  - Zhang KM
AUID- ORCID: 0000-0001-9525-9944
AD  - Institute of Dermatology Taiyuan City Central Hospital Shanxi Key Laboratory for 
      Immunological Dermatosis Taiyuan China.
FAU - Wang, G
AU  - Wang G
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
FAU - Li, B
AU  - Li B
AUID- ORCID: 0000-0002-8080-9883
AD  - Department of Dermatology Xijing Hospital Fourth Military Medical University 
      Xi'an China.
LA  - eng
PT  - Journal Article
DEP - 20211116
PL  - England
TA  - Skin Health Dis
JT  - Skin health and disease
JID - 9918227353706676
PMC - PMC9060015
COIS- The authors have no potential conflict of interest to declare.
EDAT- 2022/06/07 06:00
MHDA- 2022/06/07 06:01
PMCR- 2021/11/16
CRDT- 2022/06/06 14:05
PHST- 2021/04/08 00:00 [received]
PHST- 2021/08/05 00:00 [revised]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2022/06/06 14:05 [entrez]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/06/07 06:01 [medline]
PHST- 2021/11/16 00:00 [pmc-release]
AID - SKI264 [pii]
AID - 10.1002/ski2.64 [doi]
PST - epublish
SO  - Skin Health Dis. 2021 Nov 16;1(4):e64. doi: 10.1002/ski2.64. eCollection 2021 
      Dec.