PMID- 35664353
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220716
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2022
DP  - 2022
TI  - Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and 
      Viral Infections.
PG  - 9710376
LID - 10.1155/2022/9710376 [doi]
LID - 9710376
AB  - The human leukocyte antigen (HLA) system is one of the most crucial host factors 
      influencing disease progression in bacterial and viral infections. This review 
      provides the basic concepts of the structure and function of HLA molecules in 
      humans. Here, we highlight the main findings on the associations between HLA 
      class I and class II alleles and susceptibility to important infectious diseases 
      such as tuberculosis, leprosy, melioidosis, Staphylococcus aureus infection, 
      human immunodeficiency virus infection, coronavirus disease 2019, hepatitis B, 
      and hepatitis C in populations worldwide. Finally, we discuss challenges in HLA 
      typing to predict disease outcomes in clinical implementation. Evaluation of the 
      impact of HLA variants on the outcome of bacterial and viral infections would 
      improve the understanding of pathogenesis and identify those at risk from 
      infectious diseases in distinct populations and may improve the individual 
      treatment.
CI  - Copyright (c) 2022 Sadeep Medhasi and Narisara Chantratita.
FAU - Medhasi, Sadeep
AU  - Medhasi S
AUID- ORCID: 0000-0002-1082-5327
AD  - Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol 
      University, Bangkok, Thailand.
FAU - Chantratita, Narisara
AU  - Chantratita N
AUID- ORCID: 0000-0003-3906-7379
AD  - Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol 
      University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220526
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - *COVID-19/genetics
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II
MH  - Humans
PMC - PMC9162874
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/06/07 06:00
MHDA- 2022/06/09 06:00
PMCR- 2022/05/26
CRDT- 2022/06/06 14:12
PHST- 2022/01/10 00:00 [received]
PHST- 2022/05/08 00:00 [accepted]
PHST- 2022/06/06 14:12 [entrez]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/05/26 00:00 [pmc-release]
AID - 10.1155/2022/9710376 [doi]
PST - epublish
SO  - J Immunol Res. 2022 May 26;2022:9710376. doi: 10.1155/2022/9710376. eCollection 
      2022.