PMID- 35668334
OWN - NLM
STAT- MEDLINE
DCOM- 20220915
LR  - 20220915
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 47
IP  - 10
DP  - 2022 Oct
TI  - Catalpol Exerts Antidepressant-Like Effects by Enhancing Anti-oxidation and 
      Neurotrophy and Inhibiting Neuroinflammation via Activation of HO-1.
PG  - 2975-2991
LID - 10.1007/s11064-022-03641-w [doi]
AB  - Catalpol is an iridoid glycoside with rich content, rich nutrition, and numerous 
      biological activities in Rehmanniae Radix contained in classic antidepressant 
      prescriptions in Chinese clinical medicine. Catalpol has been confirmed 
      previously its exact antidepressant-like effect involved heme oxygenase (HO)-1, 
      but its antidepressant molecular targets and mechanism are still unclear. Here, 
      catalpol's antidepressant-like molecular target was diagnosed and confirmed by 
      ZnPP intervention [the antagonist of HO-1, (10 mug/rat), intracerebroventricular] 
      for the first time, and its molecule mechanism network was determined through 
      HO-1 related pathway and molecules in the hippocampus. Results showed that ZnPP 
      significantly abolished catalpol's (10 mg/kg) reversal on depressive-like 
      behaviors of chronic unpredictable mild stress rats, abolished catalpol's 
      up-regulation on the phosphorylation level of extracellular regulated protein 
      kinases (ERK)1/2 and brain-derived neurotrophic factor (BDNF)'s receptor 
      tropomyosin-related kinase B (TrkB), the nuclear expression level of nuclear 
      factor E 2-related factor 2 (Nrf2), the levels of anti-oxidant factors (such as 
      HO-1, SOD, GPX, GST, GSH) and BDNF, and abolished catalpol's down-regulation on 
      the levels of peroxide and neuroinflammation factors [cyclooxygenase-2 (COX-2), 
      induced nitrogen monoxide synthase (iNOS), nitric oxide (NO)]. Thus, HO-1 could 
      serve as an important potential molecular target for catalpol's 
      antidepressant-like process, and the antidepressant-like mechanism of catalpol 
      could at least involve the activation of HO-1 triggering the up-regulation of the 
      ERK1/2/Nrf2/HO-1 pathway-related factors to enhance the anti-oxidant defense, 
      triggering the down-regulation of the COX-2/iNOS/NO pathway-related factors to 
      inhibit neuroinflammation, and triggering the up-regulation of the BDNF/TrkB 
      pathway to enhance neurotrophy.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Wu, Xiaohui
AU  - Wu X
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China.
FAU - Liu, Chen
AU  - Liu C
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China.
FAU - Wang, Junming
AU  - Wang J
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China. mjw98_2010@163.com.
AD  - Co-Construction Collaborative Innovation Center for Chinese Medicine and 
      Respiratory Diseases by Henan and Education Ministry of People's Republic of 
      China, Henan University of Chinese Medicine, Zhengzhou, 450046, China. 
      mjw98_2010@163.com.
FAU - Guan, Yuechen
AU  - Guan Y
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China.
FAU - Song, Lingling
AU  - Song L
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China.
FAU - Chen, Rongxing
AU  - Chen R
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China.
FAU - Gong, Mingzhu
AU  - Gong M
AD  - College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, 
      Zhengzhou, 450046, China.
LA  - eng
GR  - 81773298/National Natural Science Foundation of China/
GR  - 00104311-2021-1-43/Zhongjing High-level Talent Special Fund of Henan University 
      of Chinese Medicine/
GR  - 2014GGJS-072/Funding Scheme for Yong Key Teachers of Colleges and Universities in 
      Henan Province/
PT  - Journal Article
DEP - 20220606
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iridoid Glucosides)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 2415-24-9 (catalpol)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Antioxidants
MH  - *Brain-Derived Neurotrophic Factor/metabolism
MH  - Cyclooxygenase 2/metabolism
MH  - Heme Oxygenase-1/metabolism
MH  - Iridoid Glucosides
MH  - *NF-E2-Related Factor 2/metabolism
MH  - Neuroinflammatory Diseases
MH  - Nitric Oxide/metabolism
MH  - Rats
OTO - NOTNLM
OT  - Antagonist
OT  - Anti-inflammatory
OT  - Anti-oxidant
OT  - Heme oxygenase-1
OT  - Molecular targets
OT  - Neurotrophic factor
EDAT- 2022/06/07 06:00
MHDA- 2022/09/16 06:00
CRDT- 2022/06/06 23:27
PHST- 2021/11/20 00:00 [received]
PHST- 2022/04/02 00:00 [accepted]
PHST- 2022/03/30 00:00 [revised]
PHST- 2022/06/07 06:00 [pubmed]
PHST- 2022/09/16 06:00 [medline]
PHST- 2022/06/06 23:27 [entrez]
AID - 10.1007/s11064-022-03641-w [pii]
AID - 10.1007/s11064-022-03641-w [doi]
PST - ppublish
SO  - Neurochem Res. 2022 Oct;47(10):2975-2991. doi: 10.1007/s11064-022-03641-w. Epub 
      2022 Jun 6.