PMID- 35669166
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240201
IS  - 2090-2840 (Print)
IS  - 2090-2859 (Electronic)
IS  - 2090-2840 (Linking)
VI  - 2022
DP  - 2022
TI  - Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in 
      Levels of Treg-Related Cytokines.
PG  - 7344375
LID - 10.1155/2022/7344375 [doi]
LID - 7344375
AB  - OBJECTIVE: Analysis of clinical factors and changes in regulatory T cell 
      (Treg)-related cytokine levels in transfusion-associated acute lung injury 
      (TRALI). METHODS: 62 patients who underwent blood transfusion and developed TRALI 
      (TRALI group) in our hospital between January 2018 and December 2021 and 58 
      patients who did not develop TRALI (non-TRALI group) from blood transfusion were 
      selected to collect clinical data from patients and construct a logistic 
      regression model to analyze clinical risk factors for TRALI. Based on the 
      prognosis of TRALI patients, they were divided into survival group (50 cases) and 
      death group (12 cases), and serum CD4 + CD25 + Treg and Treg-related cytokines 
      (interleukin 10 (IL-10), transforming growth factor-beta (TGF-beta)) levels were 
      compared between the two groups, and the correlation between CD4 + CD25 + Treg 
      and IL-10 and TGF-beta was analyzed by Pearson. RESULTS: The differences in smoking 
      history, human leukocyte antigen (HLA) antibody II, pretransfusion shock, and 
      CD4 + CD25 + Treg between the TRALI group and non-TRALI group were statistically 
      significant (P < 0.05). Logistic regression analysis showed that HLA antibody II 
      and increased CD4 + CD25 + Treg were independent risk factors of TRALI (P < 
      0.05). The levels of CD4 + CD25 + Treg, IL-10, and TGF-beta in the death group were 
      significantly higher than those in the survival group (P < 0.05). 
      CD4 + CD25 + Treg was positively correlated with levels of IL-10 and TGF-beta (P < 
      0.05). CONCLUSION: Elevated HLA antibody II and CD4 + CD25 + Treg are the main 
      clinical risk factors for TRALI, and CD4 + CD25 + Treg may be involved in 
      immunosuppression by increasing the expression levels of IL-10 and TGF-beta. Early 
      clinical monitoring of changes in Treg-related cytokine levels can provide some 
      guidance for prognostic assessment of TRALI patients.
CI  - Copyright (c) 2022 Lifang Sun and Yu Liu.
FAU - Sun, Lifang
AU  - Sun L
AD  - Department of Blood Transfusion, Tianshui First People's Hospital, Tianshui, 
      Gansu 741000, China.
FAU - Liu, Yu
AU  - Liu Y
AUID- ORCID: 0000-0003-0444-4795
AD  - Department of Laboratory, Tianshui First People's Hospital, Tianshui, Gansu 
      741000, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20220527
PL  - Egypt
TA  - Emerg Med Int
JT  - Emergency medicine international
JID - 101567070
RIN - Emerg Med Int. 2024 Jan 24;2024:9796183. PMID: 38298941
PMC - PMC9167010
COIS- The authors declare no conflicts of interest, financial or otherwise.
EDAT- 2022/06/08 06:00
MHDA- 2022/06/08 06:01
PMCR- 2022/05/27
CRDT- 2022/06/07 02:26
PHST- 2022/03/30 00:00 [received]
PHST- 2022/04/27 00:00 [revised]
PHST- 2022/05/05 00:00 [accepted]
PHST- 2022/06/07 02:26 [entrez]
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/06/08 06:01 [medline]
PHST- 2022/05/27 00:00 [pmc-release]
AID - 10.1155/2022/7344375 [doi]
PST - epublish
SO  - Emerg Med Int. 2022 May 27;2022:7344375. doi: 10.1155/2022/7344375. eCollection 
      2022.