PMID- 35669240
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1687-8450 (Print)
IS  - 1687-8469 (Electronic)
IS  - 1687-8450 (Linking)
VI  - 2022
DP  - 2022
TI  - The Influence of Heavy Metals on Gastric Tumorigenesis.
PG  - 6425133
LID - 10.1155/2022/6425133 [doi]
LID - 6425133
AB  - OBJECTIVES: This study aimed to observe the relationship among heavy metals 
      concentration, microsatellite instability (MSI), and human epidermal growth 
      factor receptor type 2 (HER2) gene amplification in gastric cancer (GC) patients. 
      METHODS: The concentrations of 18 heavy metals in the plasma of GC patients and 
      healthy controls were measured by inductive coupled plasma emission spectrometry 
      (ICP-MS). MSI detection was conducted by detecting 5 microsatellite repeat 
      markers by PCR analysis. HER2 gene amplification was detected by fluorescence in 
      situ hybridization (FISH). The relationship among heavy metal elements, tumor 
      biomarkers, HER2 amplification, and MSI status was analyzed by Pearson 
      correlation analysis. RESULTS: A total of 105 GC patients and 62 healthy controls 
      were recruited in this study. The concentration of arsenic (As), chromium (Cr), 
      cuprum (Cu), mercury (Hg), manganese (Mn), lead (Pb), stibium (Sb), selenium 
      (Se), stannum (Sn), strontium (Sr), thallium (Tl), vanadium (V), and zinc (Zn) 
      were significantly different between GC patients and controls. Among 105 GC 
      patients, including 87 microsatellite-stable (MSS) samples and 18 MSI samples, 
      the concentration of Ga is significantly higher in the MSI group than that in the 
      MSS group. Meanwhile, in 97 GC patients having detected HER2 gene amplification, 
      69 of 97 had negative HER2 gene amplification and the rest 28 GC patients had 
      positive HER2 gene amplification. The concentration of Hg, Sn, and Tl is 
      noticeably higher in the HER2 positive group than in the HER2 negative group. 
      Only Sb was positively correlated with MSI, but none of these heavy metals was 
      correlated with HER2 gene amplification. CONCLUSIONS: The results indicated that 
      Sb has significant positive correlation with the MSI status, which suggests that 
      Sb may cause MSI in GC. However, further research studies are required to 
      elucidate the mechanisms in the near feature.
CI  - Copyright (c) 2022 Liang Wang et al.
FAU - Wang, Liang
AU  - Wang L
AUID- ORCID: 0000-0001-7430-3512
AD  - Department of Gastrointestinal Surgery, Heping Hospital, Changzhi Medical 
      College, Changzhi 046000, China.
FAU - Miao, Congxiu
AU  - Miao C
AUID- ORCID: 0000-0002-0021-1559
AD  - Department of Reproductive Genetics, Heping Hospital, Changzhi Medical College, 
      Key Labrotory of Reproduction Engineer of Shanxi Health Committee, Changzhi 
      046000, China.
FAU - He, Yuan
AU  - He Y
AUID- ORCID: 0000-0002-9075-9912
AD  - Department of Gastrointestinal Surgery, Heping Hospital, Changzhi Medical 
      College, Changzhi 046000, China.
FAU - Li, Hanglong
AU  - Li H
AUID- ORCID: 0000-0003-1062-7192
AD  - Department of Gastrointestinal Surgery, Heping Hospital, Changzhi Medical 
      College, Changzhi 046000, China.
FAU - Zhang, Shasha
AU  - Zhang S
AUID- ORCID: 0000-0002-1054-8884
AD  - Department of Gastrointestinal Surgery, Heping Hospital, Changzhi Medical 
      College, Changzhi 046000, China.
FAU - Li, Keyan
AU  - Li K
AUID- ORCID: 0000-0001-9145-5294
AD  - Department of Gastrointestinal Surgery, Heping Hospital, Changzhi Medical 
      College, Changzhi 046000, China.
FAU - Liu, Huimin
AU  - Liu H
AUID- ORCID: 0000-0001-7118-5020
AD  - Shanghai Biotecan Pharmaceuticals Co., Ltd., 180 Zhangheng Road, Shanghai 201204, 
      China.
AD  - Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 201204, China.
FAU - Li, Wushuang
AU  - Li W
AUID- ORCID: 0000-0003-4000-0411
AD  - Shanghai Biotecan Pharmaceuticals Co., Ltd., 180 Zhangheng Road, Shanghai 201204, 
      China.
AD  - Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 201204, China.
FAU - Zhao, Jiangman
AU  - Zhao J
AUID- ORCID: 0000-0001-6572-6177
AD  - Shanghai Biotecan Pharmaceuticals Co., Ltd., 180 Zhangheng Road, Shanghai 201204, 
      China.
AD  - Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 201204, China.
FAU - Xu, Yue
AU  - Xu Y
AUID- ORCID: 0000-0002-5461-5495
AD  - Shanghai Biotecan Pharmaceuticals Co., Ltd., 180 Zhangheng Road, Shanghai 201204, 
      China.
AD  - Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 201204, China.
FAU - Tang, Hui
AU  - Tang H
AUID- ORCID: 0000-0002-7429-1627
AD  - Shanghai Biotecan Pharmaceuticals Co., Ltd., 180 Zhangheng Road, Shanghai 201204, 
      China.
AD  - Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 201204, China.
FAU - Zhao, Qiang
AU  - Zhao Q
AUID- ORCID: 0000-0001-9069-7515
AD  - Department of Gastrointestinal Surgery, Heping Hospital, Changzhi Medical 
      College, Changzhi 046000, China.
LA  - eng
PT  - Journal Article
DEP - 20220528
PL  - Egypt
TA  - J Oncol
JT  - Journal of oncology
JID - 101496537
PMC - PMC9167133
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/06/08 06:00
MHDA- 2022/06/08 06:01
PMCR- 2022/05/28
CRDT- 2022/06/07 02:29
PHST- 2022/01/06 00:00 [received]
PHST- 2022/05/01 00:00 [revised]
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/06/07 02:29 [entrez]
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/06/08 06:01 [medline]
PHST- 2022/05/28 00:00 [pmc-release]
AID - 10.1155/2022/6425133 [doi]
PST - epublish
SO  - J Oncol. 2022 May 28;2022:6425133. doi: 10.1155/2022/6425133. eCollection 2022.