PMID- 35669361
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - Association Between Sleep Duration and Albuminuria in Patients with Type 2 
      Diabetes: A Cross-Sectional Study in Ningbo, China.
PG  - 1667-1675
LID - 10.2147/DMSO.S366064 [doi]
AB  - PURPOSE: Type 2 diabetes mellitus (T2DM) can lead to microvascular complications 
      including diabetic kidney disease. Albuminuria is an important marker to diagnose 
      kidney injury in T2DM patients and healthy sleep duration is important for 
      maintaining good health in patients with T2DM. However, the association between 
      sleep duration and albuminuria in T2DM patients is unclear. Thus, this study 
      aimed to investigate the association between sleep duration and albuminuria in 
      patients with T2DM in Ningbo, China. METHODS: A cross-sectional study was 
      conducted at National Metabolic Management Centre (MMC) - Ningbo First Hospital 
      from March 2018 to February 2021. Adult patients with T2DM were included in the 
      study. The sleep duration (daytime and nocturnal) was self-reported. Albuminuria 
      was defined as the presence of urinary albumin-creatinine ratio >/=30 mg/g. 
      Logistic regression analyses were performed to identify the association. RESULTS: 
      There were 2688 T2DM patients in the study. In the unadjusted model (1), the odds 
      of albuminuria increased with the daytime sleep duration (31-60 minutes: OR 1.36, 
      95% CI 1.09-1.71; >/=61 minutes: 1.73, 1.33-2.24). Similarly, after adjusting for 
      age and sex (model 2), the odds of albuminuria increased with the daytime sleep 
      duration (31-60 minutes: 1.34, 1.07-1.68; >/=61 minutes: 1.69, 1.30-2.20). After 
      adjusting for age, sex, physical activity, smoking, alcohol drinking, 
      overweight/obesity, hypertension, hyperuricaemia, duration of T2DM, glycated 
      haemoglobin, angiotensin-converting enzyme inhibitors/angiotensin receptor 
      blocker usage and nocturnal sleep duration (model 3), the odds of albuminuria 
      increased with the daytime sleep duration (31-60 minutes: 1.33, 1.04-1.71; >/=61 
      minutes: 1.71, 1.29-2.26). However, no relationship was found between nocturnal 
      sleep duration and albuminuria. CONCLUSION: Longer daytime sleep is found to be 
      associated with albuminuria in patients with T2DM in Ningbo, China but no 
      association is found between nocturnal sleep duration and albuminuria. The 
      findings are exploratory, and there is a need for longitudinal studies on this 
      topic.
CI  - (c) 2022 Li et al.
FAU - Li, Xueyu
AU  - Li X
AD  - Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, 
      People's Republic of China.
AD  - Medical School, Ningbo University, Ningbo, People's Republic of China.
FAU - Chattopadhyay, Kaushik
AU  - Chattopadhyay K
AUID- ORCID: 0000-0002-3235-8168
AD  - Lifespan and Population Health Academic Unit, School of Medicine, University of 
      Nottingham, Nottingham, UK.
FAU - Qian, Xingjun
AU  - Qian X
AD  - Health Management Centre, Ningbo First Hospital, Ningbo, People's Republic of 
      China.
FAU - Yu, Jingjia
AU  - Yu J
AD  - Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, 
      People's Republic of China.
FAU - Xu, Miao
AU  - Xu M
AUID- ORCID: 0000-0003-2411-9295
AD  - Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, 
      People's Republic of China.
FAU - Li, Li
AU  - Li L
AUID- ORCID: 0000-0001-6301-3544
AD  - Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, 
      People's Republic of China.
FAU - Sun, Jing
AU  - Sun J
AUID- ORCID: 0000-0002-0097-2438
AD  - School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, 
      Australia.
AD  - Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, 
      Australia.
FAU - Li, Jialin
AU  - Li J
AUID- ORCID: 0000-0001-6930-9530
AD  - Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220530
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9166454
OTO - NOTNLM
OT  - China
OT  - albuminuria
OT  - sleep
OT  - type 2 diabetes mellitus
COIS- Xueyu Li and Kaushik Chattopadhyay are co-first authors for this study. The 
      authors report no conflicts of interest in this work.
EDAT- 2022/06/08 06:00
MHDA- 2022/06/08 06:01
PMCR- 2022/05/30
CRDT- 2022/06/07 02:32
PHST- 2022/03/11 00:00 [received]
PHST- 2022/05/24 00:00 [accepted]
PHST- 2022/06/07 02:32 [entrez]
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/06/08 06:01 [medline]
PHST- 2022/05/30 00:00 [pmc-release]
AID - 366064 [pii]
AID - 10.2147/DMSO.S366064 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 May 30;15:1667-1675. doi: 10.2147/DMSO.S366064. 
      eCollection 2022.