PMID- 35669490
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal 
      Disease.
PG  - 852822
LID - 10.3389/fnins.2022.852822 [doi]
LID - 852822
AB  - Dynamic functional connectivity (FC) analysis can capture time-varying properties 
      of connectivity; however, studies focusing on dynamic FC in patients with 
      end-stage renal disease (ESRD) are very limited. This is the first study to 
      explore the dynamic aspects of whole-brain FC and topological properties in ESRD 
      patients. Resting-state functional magnetic resonance imaging data were acquired 
      from 100 ESRD patients [50 hemodialysis (HD) patients and 50 non-dialysis 
      patients] and 64 healthy controls (HCs). Independent component analysis, a 
      sliding-window approach and graph-theory methods were used to study the dynamic 
      FC properties. The intrinsic brain FC were clustered into four configuration 
      states. Compared with HCs, both patient groups spent longer time in State 3, in 
      which decreased FC between subnetworks of the default mode network (DMN) and 
      between the dorsal DMN and language network was observed in these patients, and a 
      further reduction in FC between the DMN subnetworks was found in HD patients 
      compared to non-dialysis patients. The number of transitions and the variability 
      of global and local efficiency progressively decreased from that in HCs to that 
      of non-dialysis patients to that of HD patients. The completion time of Trail 
      Making Test A and Trail Making Test B positively correlated with the mean dwell 
      time of State 3 and negatively correlated with the number of transitions in ESRD 
      patients. Our findings suggest impaired functional flexibility of network 
      connections and state-specific FC disruptions in patients with ESRD, which may 
      underlie their cognitive deficits. HD may have an adverse effect on time-varying 
      FC.
CI  - Copyright (c) 2022 Li, Yan, Yue, Zhang, Ren and Wu.
FAU - Li, Xuekun
AU  - Li X
AD  - Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical 
      University, Weihui, China.
FAU - Yan, Ruifang
AU  - Yan R
AD  - Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical 
      University, Weihui, China.
FAU - Yue, Zheng
AU  - Yue Z
AD  - Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical 
      University, Weihui, China.
FAU - Zhang, Meng
AU  - Zhang M
AD  - Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical 
      University, Weihui, China.
FAU - Ren, Jipeng
AU  - Ren J
AD  - Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical 
      University, Weihui, China.
FAU - Wu, Baolin
AU  - Wu B
AD  - Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical 
      University, Weihui, China.
LA  - eng
PT  - Journal Article
DEP - 20220520
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9163405
OTO - NOTNLM
OT  - dynamic functional connectivity
OT  - end-stage renal disease
OT  - graph theory
OT  - hemodialysis
OT  - resting-state functional magnetic resonance imaging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/08 06:00
MHDA- 2022/06/08 06:01
PMCR- 2022/01/01
CRDT- 2022/06/07 02:37
PHST- 2022/01/11 00:00 [received]
PHST- 2022/04/06 00:00 [accepted]
PHST- 2022/06/07 02:37 [entrez]
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/06/08 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.852822 [doi]
PST - epublish
SO  - Front Neurosci. 2022 May 20;16:852822. doi: 10.3389/fnins.2022.852822. 
      eCollection 2022.