PMID- 35669761
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220807
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 10
DP  - 2022
TI  - Living Alone Is Not Associated With Cardiovascular Events and Hypoglycemia in 
      Patients With Type 2 Diabetes Mellitus.
PG  - 883383
LID - 10.3389/fpubh.2022.883383 [doi]
LID - 883383
AB  - OBJECTIVE: Living alone is often associated with reduced social support. However, 
      there are limited data on the relationship between living alone and 
      cardiovascular events or hypoglycemia in patients with type 2 diabetes mellitus 
      (T2DM). This study reports a post-hoc analysis of the "Action to Control 
      Cardiovascular Risk in Diabetes (ACCORD)" study. RESEARCH DESIGN AND METHODS: The 
      Cox proportional hazard models were used to compare the hazard ratios (HRs) for 
      the adverse health events selected as primary endpoints in the study 
      participants; these were compared between those living alone and those living 
      with others. The primary outcomes were hypoglycemia requiring any assistance 
      (HAA), hypoglycemia requiring medical assistance (HMA), and major cardiovascular 
      events (MACEs, including cardiac death, non-fatal myocardial infarction (MI), and 
      non-fatal stroke). Our study included 10,249 participants (2,078 living alone) 
      with a follow-up period of 4.91 +/- 1.22 years. RESULTS: After a multivariable 
      adjustment, the risk of HAA, HMA, and MACEs did not differ significantly between 
      participants living alone and those living with others (HAA, HR: 0.88, 95% CI: 
      0.75-1.04, P = 0.13; HMA, HR: 1.11, 95% CI: 0.92-1.34, P = 0.26; MACEs, HR: 0.98, 
      95% CI: 0.80-1.19, P = 0.82). Participants living alone had higher levels of 
      glycated hemoglobin in the middle follow-up period than those living with others. 
      CONCLUSIONS: In patients with T2DM, living alone did not increase the risk of 
      cardiovascular events (cardiac death, non-fatal MI, or non-fatal stroke) and 
      hypoglycemia. Patients living alone had higher Hb1AC levels than those living 
      with others. Clinicians should consider an effective blood glucose control 
      regardless of their living arrangement.
CI  - Copyright (c) 2022 Zhu, Peng and Xing.
FAU - Zhu, Zhaowei
AU  - Zhu Z
AD  - Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Peng, Zhenyu
AU  - Peng Z
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha, China.
AD  - Emergency Medicine and Difficult Diseases Institute, Central South University, 
      Changsha, China.
FAU - Xing, Zhenhua
AU  - Xing Z
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha, China.
AD  - Emergency Medicine and Difficult Diseases Institute, Central South University, 
      Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220520
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Death
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Home Environment
MH  - Humans
MH  - *Hypoglycemia/chemically induced/complications
MH  - Hypoglycemic Agents/therapeutic use
MH  - *Stroke/chemically induced/complications
PMC - PMC9163407
OTO - NOTNLM
OT  - hypoglycemia requiring any assistance
OT  - hypoglycemia requiring medical assistance
OT  - living alone
OT  - major cardiovascular events
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/08 06:00
MHDA- 2022/06/09 06:00
PMCR- 2022/05/20
CRDT- 2022/06/07 02:44
PHST- 2022/02/28 00:00 [received]
PHST- 2022/04/19 00:00 [accepted]
PHST- 2022/06/07 02:44 [entrez]
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/05/20 00:00 [pmc-release]
AID - 10.3389/fpubh.2022.883383 [doi]
PST - epublish
SO  - Front Public Health. 2022 May 20;10:883383. doi: 10.3389/fpubh.2022.883383. 
      eCollection 2022.