PMID- 35671459
OWN - NLM
STAT- MEDLINE
DCOM- 20220914
LR  - 20221021
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 56
IP  - 12
DP  - 2022 Jun 21
TI  - Decomposition Products of the Initiator Bis(2,4-dichlorobenzoyl)peroxide in the 
      Silicone Industry: Human Biomonitoring in Plasma and Urine of Workers.
PG  - 8518-8527
LID - 10.1021/acs.est.2c01530 [doi]
AB  - Bis(2,4-dichlorobenzoyl)peroxide (2,4-DCBP) is used as an initiator for silicone 
      rubber production. During hot curing, 2,4-DCBP decomposes into 
      2,4-dichlorobenzoic acid, 1,3-dichlorobenzene, and the polychlorinated biphenyl 
      (PCB) congeners PCB-47, PCB-51, and PCB-68. The extent of occupational exposure 
      to these decomposition products has not been investigated yet. We determined for 
      the first time the corresponding internal exposure of employees (n = 104) of a 
      German silicone rubber facility by human biomonitoring in plasma and urine. 
      Collected samples were investigated by gas chromatography/mass spectrometry for 
      levels of PCBs in plasma and by liquid chromatography/tandem mass spectrometry 
      for urinary post-shift levels of 2,4-dichlorobenzoic acid (2,4-DCBA) and the 
      metabolites 3,5-dichlorocatechol (3,5-DCK), 2,4-dichlorophenol (2,4-DCP), and 
      3,5-dichlorophenol (3,5-DCP). PCB-47 and PCB-68 levels correlated significantly 
      and were found in >97% of all samples with maximum values of 4.43 and 0.77 mug/L, 
      respectively. 2,4-DCBA, 3,5-DCK, 2,4-DCP, and 3,5-DCP were quantified in >80% of 
      all urine samples with maximum levels of 1.46; 26.92; 7.68; and 0.39 mg/L, 
      respectively. There is a considerable uptake of decomposition products of 
      2,4-DCBP in workers of a silicone rubber facility, affecting employees in all 
      work areas. Individual levels depended on the work task. Considering the 
      carcinogenic potential of PCBs, the workers' additional exposure to PCB-47 and 
      PCB-68 might be of concern.
FAU - Schettgen, Thomas
AU  - Schettgen T
AUID- ORCID: 0000-0003-1256-1713
AD  - Institute for Occupational, Social and Environmental Medicine, Medical Faculty, 
      RWTH Aachen University, Aachen 52074, Germany.
FAU - Esser, Andre
AU  - Esser A
AD  - Institute for Occupational, Social and Environmental Medicine, Medical Faculty, 
      RWTH Aachen University, Aachen 52074, Germany.
FAU - Alt, Anne
AU  - Alt A
AD  - Institute for Occupational, Social and Environmental Medicine, Medical Faculty, 
      RWTH Aachen University, Aachen 52074, Germany.
FAU - Randerath, Isabella
AU  - Randerath I
AD  - Institute for Occupational, Social and Environmental Medicine, Medical Faculty, 
      RWTH Aachen University, Aachen 52074, Germany.
FAU - Kraus, Thomas
AU  - Kraus T
AD  - Institute for Occupational, Social and Environmental Medicine, Medical Faculty, 
      RWTH Aachen University, Aachen 52074, Germany.
FAU - Ziegler, Patrick
AU  - Ziegler P
AD  - Institute for Occupational, Social and Environmental Medicine, Medical Faculty, 
      RWTH Aachen University, Aachen 52074, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220607
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Peroxides)
RN  - 0 (Silicone Elastomers)
RN  - 133-14-2 (bis(2,4-dichlorobenzoyl)peroxide)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - W9WZN9A0GM (Benzoyl Peroxide)
SB  - IM
MH  - Benzoyl Peroxide/analogs & derivatives
MH  - Biological Monitoring
MH  - Humans
MH  - Peroxides
MH  - *Polychlorinated Biphenyls/analysis
MH  - Silicone Elastomers
OTO - NOTNLM
OT  - 1,3-dichlorobenzene
OT  - 2,4-dichlorobenzoic acid
OT  - PCB
OT  - human biomonitoring
OT  - polychlorinated biphenyls
OT  - silicone
EDAT- 2022/06/08 06:00
MHDA- 2022/09/15 06:00
CRDT- 2022/06/07 16:32
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/09/15 06:00 [medline]
PHST- 2022/06/07 16:32 [entrez]
AID - 10.1021/acs.est.2c01530 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2022 Jun 21;56(12):8518-8527. doi: 10.1021/acs.est.2c01530. 
      Epub 2022 Jun 7.