PMID- 35671532
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20221011
IS  - 1545-3251 (Electronic)
IS  - 0066-4227 (Linking)
VI  - 76
DP  - 2022 Sep 8
TI  - Mechanisms Underlying Vibrio cholerae Biofilm Formation and Dispersion.
PG  - 503-532
LID - 10.1146/annurev-micro-111021-053553 [doi]
AB  - Biofilms are a widely observed growth mode in which microbial communities are 
      spatially structured and embedded in a polymeric extracellular matrix. Here, we 
      focus on the model bacterium Vibrio cholerae and summarize the current 
      understanding of biofilm formation, including initial attachment, matrix 
      components, community dynamics, social interactions, molecular regulation, and 
      dispersal. The regulatory network that orchestrates the decision to form and 
      disperse from biofilms coordinates various environmental inputs. These cues are 
      integrated by several transcription factors, regulatory RNAs, and 
      second-messenger molecules, including bis-(3'-5')-cyclic dimeric guanosine 
      monophosphate (c-di-GMP). Through complex mechanisms, V. cholerae weighs the 
      energetic cost of forming biofilms against the benefits of protection and social 
      interaction that biofilms provide.
FAU - Teschler, Jennifer K
AU  - Teschler JK
AD  - Department of Microbiology and Environmental Toxicology, University of 
      California, Santa Cruz, California, USA; email: fyildiz@ucsc.edu.
FAU - Nadell, Carey D
AU  - Nadell CD
AD  - Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, 
      USA.
FAU - Drescher, Knut
AU  - Drescher K
AD  - Biozentrum, University of Basel, Basel, Switzerland.
FAU - Yildiz, Fitnat H
AU  - Yildiz FH
AD  - Department of Microbiology and Environmental Toxicology, University of 
      California, Santa Cruz, California, USA; email: fyildiz@ucsc.edu.
LA  - eng
GR  - R01 AI102584/AI/NIAID NIH HHS/United States
GR  - R01 AI114261/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220607
PL  - United States
TA  - Annu Rev Microbiol
JT  - Annual review of microbiology
JID - 0372370
RN  - 0 (Bacterial Proteins)
RN  - 0 (Transcription Factors)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Bacterial Proteins/metabolism
MH  - *Biofilms/growth & development
MH  - Cyclic GMP/metabolism
MH  - Gene Expression Regulation, Bacterial
MH  - Transcription Factors/metabolism
MH  - *Vibrio cholerae/genetics/physiology
OTO - NOTNLM
OT  - Vibrio cholerae
OT  - EPS
OT  - biofilm
OT  - biofilm regulation
OT  - dispersal
OT  - emergent properties
OT  - extracellular matrix
OT  - extracellular polymeric substances
OT  - surface attachment
EDAT- 2022/06/08 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/06/07 18:02
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/06/07 18:02 [entrez]
AID - 10.1146/annurev-micro-111021-053553 [doi]
PST - ppublish
SO  - Annu Rev Microbiol. 2022 Sep 8;76:503-532. doi: 
      10.1146/annurev-micro-111021-053553. Epub 2022 Jun 7.