PMID- 35671916
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20221003
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 783
DP  - 2022 Jul 13
TI  - Prelimbic medial prefrontal cortex has bidirectional control over the expression 
      of behavioral sensitization to 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) 
      depending on the context of drug administration.
PG  - 136710
LID - S0304-3940(22)00267-1 [pii]
LID - 10.1016/j.neulet.2022.136710 [doi]
AB  - Behavioral sensitization to MDMA is observed in the vast majority of rats if 
      tested in the same environment in which previous MDMA exposure occurred, but not 
      if tested in a novel, unpaired context. Previous studies have revealed a critical 
      role for the prelimbic region of medial prefrontal cortex (PL) in the expression 
      of sensitization to MDMA, but these studies assessed sensitization only in 
      MDMA-paired environments. Given that PL activity can both facilitate and suppress 
      behavior depending on context, we tested the hypothesis that PL has bidirectional 
      control over the expression of locomotor sensitization to MDMA depending on the 
      context of drug administration. Rats were treated with either saline or MDMA 
      (5.0 mg/kg) twice daily for 5 days, in either their home cages (unpaired groups) 
      or the activity monitors that were used for tests of sensitization on challenge 
      days (paired groups). Prior to MDMA challenge injections (2.5 mg/kg; at  approximately  2 weeks 
      of withdrawal), rats received bilateral PL microinjections of either lidocaine 
      (100 mug/0.5 mul/side) or physiological saline (0.5 mul/side). Locomotor activity in 
      response to MDMA challenge was unaffected by PL inactivation in saline pretreated 
      rats. However, PL inactivation caused a decrease in locomotion to the challenge 
      injection in MDMA/paired rats and an increase in locomotion in MDMA/unpaired 
      rats. These results establish a novel role for PL in suppressing the expression 
      of behavioral sensitization when subjects are challenged in a drug-unpaired 
      context, adding to the literature implicating PL activity in both the expression 
      and inhibition of other drug-related behaviors.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Plocinski, Jacob A
AU  - Plocinski JA
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
FAU - Ball, Kevin T
AU  - Ball KT
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA. Electronic address: kball@bloomu.edu.
LA  - eng
GR  - R15 DA035432/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220606
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - *Hallucinogens/pharmacology
MH  - Humans
MH  - Motor Activity
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Prefrontal Cortex/physiology
MH  - Rats
OTO - NOTNLM
OT  - Context
OT  - MDMA
OT  - Medial prefrontal cortex
OT  - Prelimbic
OT  - Sensitization
EDAT- 2022/06/08 06:00
MHDA- 2022/06/29 06:00
CRDT- 2022/06/07 19:25
PHST- 2021/12/24 00:00 [received]
PHST- 2022/05/04 00:00 [revised]
PHST- 2022/06/02 00:00 [accepted]
PHST- 2022/06/08 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
PHST- 2022/06/07 19:25 [entrez]
AID - S0304-3940(22)00267-1 [pii]
AID - 10.1016/j.neulet.2022.136710 [doi]
PST - ppublish
SO  - Neurosci Lett. 2022 Jul 13;783:136710. doi: 10.1016/j.neulet.2022.136710. Epub 
      2022 Jun 6.