PMID- 35673416 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230916 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 21 IP - 1 DP - 2022 Jun TI - The global scientific publications on gut microbiota in type 2 diabetes; a bibliometric, Scientometric, and descriptive analysis. PG - 13-32 LID - 10.1007/s40200-021-00920-1 [doi] AB - BACKGROUND: Modifying gut dysbiosis has achieved great success in managing type 2 diabetes mellitus (T2DM) and also T2DM affected the gut microbial composition. OBJECTIVES: To determine the research trend of scientific publications on the relationship between gut microbiota and T2DM through a bibliometric and descriptive approach. METHOD: We included originals and reviews related to both topics of gut microbiota and T2DM through searching in Scopus up to 31 December 2019 and then characterized their bibliometric profiles including the number of publications, citations, institutions, journals, countries, and the collaboration network of authors, countries, terms and keywords. Moreover, we performed a descriptive evaluation of the clinical trials based on their intervention type and its influence on gut dysbiosis. RESULTS: We achieved 877 articles (436 originals and 441 reviews) according to our inclusion criteria. The annual publications were constantly increased over time and reached 220 publications in 2019. Out of 436 original articles, 231 animal studies and 174 human studies were found. The majority of human studies were clinical trials (n = 77) investigating the influence of drugs (n = 21), regimens (n = 21), pre/pro/symbiotic (n = 19), surgeries (n = 15), or both drug and regimen (n = 1) on gut dysbiosis. Roux-en-Y gastric bypass and metformin were assessed the most in these trials. Obesity side by side T2DM has been assessed in this area of literature based on term and keyword analyses showing their possible similar pathways mediated by gut microbiota. CONCLUSION: The exponentially growing documents on gut microbiota and T2DM had been published during the last decade and revealed gut microbiota alteration mediated antidiabetic effect of many interventions. Thus, we suggest other researchers to consider this pathway in efficacy assessment of therapeutic modalities and to find the optimal composition of gut microbiota that guarantees healthy insulin sensitivity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-021-00920-1. CI - (c) Springer Nature Switzerland AG 2021. FAU - Dehghanbanadaki, Hojat AU - Dehghanbanadaki H AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Aazami, Hossein AU - Aazami H AD - Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 AD - Scientometrics Department, FarIdea Company, Tehran, Iran. FAU - Ejtahed, Hanieh Sadat AU - Ejtahed HS AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Sohrabi, Ahmad AU - Sohrabi A AD - Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran. GRID: grid.411746.1. ISNI: 0000 0004 4911 7066 FAU - Raftar, Shahrbanoo Keshavarz Azizi AU - Raftar SKA AD - Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 AD - Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 FAU - Tarashi, Samira AU - Tarashi S AD - Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 AD - Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 FAU - Tabatabaei-Malazy, Ozra AU - Tabatabaei-Malazy O AD - Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Bahramali, Golnaz AU - Bahramali G AD - Hepatitis, AIDS and Bloodborne Diseases Department, Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 FAU - Siadat, Seyed Davar AU - Siadat SD AD - Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 AD - Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. GRID: grid.420169.8. ISNI: 0000 0000 9562 2611 FAU - Esfahani, Ensieh Nasli AU - Esfahani EN AD - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Razi, Farideh AU - Razi F AUID- ORCID: 0000-0003-2350-9574 AD - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 LA - eng PT - Journal Article DEP - 20211118 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC9167415 OTO - NOTNLM OT - Bibliometrics OT - Gut microbiota OT - Microbiome OT - Probiotic OT - Scientometrics OT - Type 2 diabetes COIS- Conflict of interestThe authors declare that they have no conflict of interest. EDAT- 2022/06/09 06:00 MHDA- 2022/06/09 06:01 PMCR- 2022/11/18 CRDT- 2022/06/08 01:57 PHST- 2021/04/27 00:00 [received] PHST- 2021/10/17 00:00 [accepted] PHST- 2022/06/08 01:57 [entrez] PHST- 2022/06/09 06:00 [pubmed] PHST- 2022/06/09 06:01 [medline] PHST- 2022/11/18 00:00 [pmc-release] AID - 920 [pii] AID - 10.1007/s40200-021-00920-1 [doi] PST - epublish SO - J Diabetes Metab Disord. 2021 Nov 18;21(1):13-32. doi: 10.1007/s40200-021-00920-1. eCollection 2022 Jun.