PMID- 35673719
OWN - NLM
STAT- MEDLINE
DCOM- 20220609
LR  - 20220609
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 51
IP  - 6
DP  - 2022 Jun 8
TI  - [Clinicopathological features of clear cell carcinoma of salivary gland in the 
      head and neck].
PG  - 494-499
LID - 10.3760/cma.j.cn112151-20211117-00837 [doi]
AB  - Objective: To investigate the clinical, histologic, immunohistochemical (IHC) and 
      molecular genetic features of clear cell carcinoma (CCC) of salivary gland in the 
      head and neck regions. Methods: Seven cases of CCC diagnosed in the Department of 
      Pathology, the First Affiliated Hospital of Nanjing Medical University from 2018 
      to 2021 were included. The clinical and pathologic data, HE sections and IHC 
      staining were reviewed, and EWSR1 gene translocation was detected by fluorescence 
      in situ hybridization (FISH). The relevant literature was also reviewed. Results: 
      There were five males and two females, with an age range of 32 to 71 years (mean 
      50 years). The tumors were located in the palate, base of tongue, subglottic, 
      right submaxillary and nasopharynx. Histologically the tumors were composed of 
      sheets, nests, and trabecular of large, monomorphic cells which possessed 
      abundant clear and eosinophilic cytoplasm. The stroma was characterized by 
      abundant hyalinized fibrous strands admixed with cellular fibrous (desmoplastic) 
      tissue. The tumor growth was infiltrative. IHC staining revealed positivity for 
      CKpan and squamous cell immunophenotypic markers (CK5/6, p63 and p40), but 
      negativity for myoepithelial markers (SMA, calponin, GFAP and CD10). The EWSR1 
      gene translocation was detected by FISH. The prognosis was excellent, with the 
      follow-up periods ranging from 8 months to 33 months. During this period, six 
      patients survived without tumor, only one patient with cervical lymph node 
      metastasis. Conclusions: CCC of salivary gland is rare and needs to be 
      differentiated from various other types of tumors containing clear cells. 
      Awareness of the histopathologic characteristics, and combined with IHC and 
      molecular genetic examination can avoid misdiagnosis. The biological behavior of 
      the tumor is indolent with a good overall prognosis.
FAU - Zhao, S
AU  - Zhao S
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Zhu, Y
AU  - Zhu Y
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Pan, M H
AU  - Pan MH
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Hua, H J
AU  - Hua HJ
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Yang, Q Y
AU  - Yang QY
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Li, X
AU  - Li X
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Li, H
AU  - Li H
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - *Adenocarcinoma, Clear Cell/pathology
MH  - Biomarkers, Tumor/genetics
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Salivary Gland Neoplasms/diagnosis/genetics
MH  - Salivary Glands/pathology
EDAT- 2022/06/09 06:00
MHDA- 2022/06/10 06:00
CRDT- 2022/06/08 02:03
PHST- 2022/06/08 02:03 [entrez]
PHST- 2022/06/09 06:00 [pubmed]
PHST- 2022/06/10 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20211117-00837 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2022 Jun 8;51(6):494-499. doi: 
      10.3760/cma.j.cn112151-20211117-00837.