PMID- 35673724
OWN - NLM
STAT- MEDLINE
DCOM- 20220609
LR  - 20220609
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 51
IP  - 6
DP  - 2022 Jun 8
TI  - [Clinicopathological and molecular genetic characteristics of nodular fasciitis 
      in unusual sites].
PG  - 524-529
LID - 10.3760/cma.j.cn112151-20210917-00688 [doi]
AB  - Objective: To study the clinicopathological, immunophenotypic and molecular 
      genetic characteristics of nodular fasciitis (NF) in unusual sites. Methods: A 
      total of 50 cases of NF diagnosed between January 2015 and January 2021 were 
      reviewed in the Department of Pathology, Henan Provincial People's Hospital, and 
      the clinical and pathologic data were analyzed. Among them, 14 cases from unusual 
      sites were included in this study. Immunohistochemical (IHC) staining was used to 
      detect the expression of related proteins, and fluorescence in situ hybridization 
      (FISH) was used to detect the breakage of the USP6 gene. Results: There were 
      seven males and seven females in the 14 NF respectively. The lesions were located 
      in the extremities, perineum, breast, wrist joints, the gap between lumbar 
      vertebra 4/5, and in eight cases there was involvement of unusual tissues (six 
      cases in skeletal muscle, one case in nerve root, and one case was 
      intravascular). The tumor boundary was unclear with infiltrating growth. 
      Spindle-shaped myofibroblasts were arranged in bundles or chaotically, with mild 
      pleomorphic, small nucleoli and various mitotic figures. The tumor stroma showed 
      collagenization to myxoid degeneration with erythrocyte extravasation and 
      infiltration of inflammatory cells. IHC staining showed that the spindle cells 
      expressed SMA focally or partially, and p16 diffusely and strongly. FISH showed 
      that 12 of 14 cases had USP6 gene breakage, and two of them occurred in the 
      intrathoracic skeletal muscle with the red signal amplification of USP6 gene. 
      Conclusions: NF in unusual sites shows similar clinicopathological and genetic 
      characteristics to classic NF, but the tumor mostly has infiltrating borders, 
      non-specific and strong expression of p16, and USP6 red signal amplification. The 
      pathological diagnosis of NF in rare sites should be highly vigilant.
FAU - Liu, Q Y
AU  - Liu QY
AD  - Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University 
      People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China.
FAU - Li, R T
AU  - Li RT
AD  - Department of Pathology, Shangqiu Hospital of Traditional Chinese Medicine, 
      Shangqiu 476000, China.
FAU - Li, Z
AU  - Li Z
AD  - Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University 
      People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China.
FAU - Xu, Z G
AU  - Xu ZG
AD  - Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University 
      People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China.
FAU - Gao, Z L
AU  - Gao ZL
AD  - Department of Pathology, People's Hospital of Xin'an, Luoyang 471800, China.
FAU - Chang, Y N
AU  - Chang YN
AD  - Department of Pathology, People's Hospital of Queshan, Zhumadian 463200, China.
FAU - Kong, L F
AU  - Kong LF
AD  - Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University 
      People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China.
LA  - chi
GR  - 202300410384/Natural Science Foundation of Henan Province/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - EC 3.4.19.12 (USP6 protein, human)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - *Fasciitis/diagnosis/genetics/pathology
MH  - Female
MH  - *Fibroma
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Molecular Biology
MH  - Ubiquitin Thiolesterase/genetics
EDAT- 2022/06/09 06:00
MHDA- 2022/06/10 06:00
CRDT- 2022/06/08 02:03
PHST- 2022/06/08 02:03 [entrez]
PHST- 2022/06/09 06:00 [pubmed]
PHST- 2022/06/10 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20210917-00688 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2022 Jun 8;51(6):524-529. doi: 
      10.3760/cma.j.cn112151-20210917-00688.