PMID- 35675471
OWN - NLM
STAT- Publisher
LR  - 20240216
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
DP  - 2022 Jun 8
TI  - Faecal microbiota transplantation is better than probiotics for tissue 
      regeneration of type 2 diabetes mellitus injuries in mice.
PG  - 1-9
LID - 10.1080/13813455.2022.2080229 [doi]
AB  - CONTEXT: Western diet and unhealthy lifestyle have contributed to the continued 
      growth of type 2 diabetes mellitus (T2DM). T2DM is associated with 
      dysbacteriosis, and studies have found that altering the gut microbiota has a 
      positive effect on treatment. OBJECTIVE: In addition to hyperglycaemia, T2DM 
      often causes damage to multiple organs. However, there are few studies on organ 
      damage from faecal microbiota transplantation (FMT). MATERIALS AND METHODS: T2DM 
      mice were divided into four groups and were given phosphate buffered saline (PBS) 
      (T2DM group), FMT (FMT group), Lactobacillus (LAB group), and Bifidobacterium 
      (BIO group) by gavage for six weeks, respectively. Mice on a normal diet (control 
      group) were gavaged with PBS for six weeks. RESULTS: After gavage treatment, FMT, 
      LAB, and BIO groups were similar in lowering glucose, endotoxemia was slightly 
      reduced, and the colonic mucus layer and liver lobules developed towards normal 
      tissue. Surprisingly, we found that the FMT group had unique effects on islet 
      cell regeneration, increased functional beta cells, and insulin sensitivity. 
      DISCUSSION AND CONCLUSION: Lactobacillus has the best glucose-lowering effect, 
      but FMT has obvious advantages in beta-cell regeneration, which provides new 
      treatment ideas for tissue damage caused by T2DM.
FAU - Wang, Yuying
AU  - Wang Y
AUID- ORCID: 0000-0002-3033-5122
AD  - Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
FAU - Yang, Zhenpeng
AU  - Yang Z
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
FAU - Tang, Huazhen
AU  - Tang H
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
FAU - Sun, Xibo
AU  - Sun X
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
FAU - Qu, Jinxiu
AU  - Qu J
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
FAU - Lu, Shuai
AU  - Lu S
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
FAU - Rao, Benqiang
AU  - Rao B
AUID- ORCID: 0000-0002-2798-2468
AD  - Department of Gastrointestinal Surgery, Capital Medical University Affiliated 
      Beijing Shijitan Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220608
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
SB  - IM
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - microbiota transplantation
OT  - regeneration
OT  - beta cells
EDAT- 2022/06/09 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/06/08 14:12
PHST- 2022/06/08 14:12 [entrez]
PHST- 2022/06/09 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
AID - 10.1080/13813455.2022.2080229 [doi]
PST - aheadofprint
SO  - Arch Physiol Biochem. 2022 Jun 8:1-9. doi: 10.1080/13813455.2022.2080229.