PMID- 35675882
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220729
IS  - 1873-1740 (Electronic)
IS  - 0033-0620 (Linking)
VI  - 72
DP  - 2022 May-Jun
TI  - Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of 
      aortic bioprostheses: An imaging finding or a complication?
PG  - 78-83
LID - S0033-0620(22)00058-5 [pii]
LID - 10.1016/j.pcad.2022.05.007 [doi]
AB  - Transcatheter aortic valve implantation is a safe and effective therapy for 
      patients with symptomatic severe aortic stenosis, with randomized data 
      demonstrating outcomes at least equivalent to surgical aortic valve replacement 
      across the spectrum of surgical risk. There has been substantial recent interest 
      in the occurrence of hypoattenuated leaflet thickening and reduced leaflet 
      motion, which are imaging features detected on computed tomography of patients 
      who have received aortic bioprostheses. These phenomena may represent subclinical 
      leaflet thrombosis with theoretical potential downstream effects on valve 
      durability or thrombotic complications in the form of stroke. This review will 
      discuss definitions, predictors, mechanisms, diagnosis, and natural history. We 
      will also examine the frequency with which hypoattenuated leaflet thickening and 
      reduced leaflet motion occur after both transcatheter and surgical aortic 
      bioprostheses, and the clinical implications and potential impact on valve 
      function, as well as strategies for prophylaxis and treatment.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Ahmad, Yousif
AU  - Ahmad Y
AD  - Yale School of Medicine, Yale University, 135 College Street, Suite 101, New 
      Haven, CT 06510, USA. Electronic address: yousif.ahmad@yale.edu.
FAU - Makkar, Raj
AU  - Makkar R
AD  - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
FAU - Sondergaard, Lars
AU  - Sondergaard L
AD  - The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220605
PL  - United States
TA  - Prog Cardiovasc Dis
JT  - Progress in cardiovascular diseases
JID - 0376442
SB  - IM
MH  - Aortic Valve/diagnostic imaging/surgery
MH  - *Aortic Valve Stenosis/complications/diagnostic imaging/surgery
MH  - *Bioprosthesis/adverse effects
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - *Thrombosis/diagnostic imaging/etiology
MH  - *Transcatheter Aortic Valve Replacement/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Leaflet thickening
OT  - Transcatheter aortic valve implantation
EDAT- 2022/06/09 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/06/08 19:23
PHST- 2022/05/29 00:00 [received]
PHST- 2022/05/29 00:00 [accepted]
PHST- 2022/06/09 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/06/08 19:23 [entrez]
AID - S0033-0620(22)00058-5 [pii]
AID - 10.1016/j.pcad.2022.05.007 [doi]
PST - ppublish
SO  - Prog Cardiovasc Dis. 2022 May-Jun;72:78-83. doi: 10.1016/j.pcad.2022.05.007. Epub 
      2022 Jun 5.