PMID- 35677871
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - Prevalence of Adverse Effects Associated With Transcranial Magnetic Stimulation 
      for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
PG  - 875591
LID - 10.3389/fpsyt.2022.875591 [doi]
LID - 875591
AB  - BACKGROUND: A growing number of studies have suggested that transcranial magnetic 
      stimulation (TMS) may represent a novel technique with both investigative and 
      therapeutic potential for autism spectrum disorder (ASD). However, a full 
      spectrum of the adverse effects (AEs) of TMS used in ASD has not been 
      specifically and systematically evaluated. OBJECTIVE: This systematic review and 
      meta-analysis was to assess the prevalence of AEs related to TMS in ASD and to 
      further explore the potentially related factors on the AEs. METHODS: A systematic 
      literature research of articles published before 31 December 2020 was conducted 
      in the databases of PubMed, Embase, Cochrane Library, Ovid, PsycINFO, Chinese 
      National Knowledge Infrastructure (CNKI), Chongqing VIP, and WANFANG DATA. AEs 
      reported in the studies were carefully examined and synthesized to understand the 
      safety and tolerability of TMS among ASD. Then, subgroup and sensitivity analyses 
      were performed to examine the potentially related factors on the AEs. PROSPERO 
      registration number: CRD42021239827. RESULTS: Eleven studies were included in the 
      meta-analysis. The pooled prevalence with 95% confidence interval (CI) of AEs was 
      calculated (overall AEs: 25%, 95% CI 18-33%; headache: 10%, 95% CI 3-19%; facial 
      discomfort: 15%, 95% CI 4-29%; irritability 21%, 95% CI 8-37%; pain at the 
      application site: 6%, 95% CI 0-19%; headedness or dizziness: 8%, 95% CI 0-23%). 
      All reported AEs were mild and transient with relatively few serious AEs and can 
      be resolved after having a rest or medication. In addition, the following 
      variables showed no significant change in overall prevalence of AEs: the purpose 
      of using TMS, mean age of participants, whether the stimulation site was 
      dorsolateral pre-frontal cortex (DLPFC), intensity of TMS, and the number of 
      stimulation sessions. CONCLUSION: The overall prevalence of reported AEs of TMS 
      among ASD was 25%. No identified ASD-specific risk factors for TMS-induced AEs 
      were found. Further studies are needed to clarify the variation in the 
      prevalence. SYSTEMATIC REVIEW REGISTRATION: 
      www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=239827, PROSPERO, 
      identifier: CRD42021239827.
CI  - Copyright (c) 2022 Huashuang, Yang, Chensheng, Jing, Bo, Dongming, Kangfu and 
      Shi-Bin.
FAU - Huashuang, Zhang
AU  - Huashuang Z
AD  - Institute for Brain Research and Rehabilitation, South China Normal University, 
      Guangzhou, China.
AD  - Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical 
      University, Foshan, China.
FAU - Yang, Li
AU  - Yang L
AD  - Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan, China.
FAU - Chensheng, Hou
AU  - Chensheng H
AD  - Institute for Brain Research and Rehabilitation, South China Normal University, 
      Guangzhou, China.
FAU - Jing, Xin
AU  - Jing X
AD  - Department of Pediatric Rehabilitation Medicine, Foshan Fosun Chancheng Hospital, 
      Foshan, China.
FAU - Bo, Chen
AU  - Bo C
AD  - Department of Cardiovascular Surgery, The People's Hospital of Gaozhou, Gaozhou, 
      China.
FAU - Dongming, Zhang
AU  - Dongming Z
AD  - Department of Neurology, Foshan Fosun Chancheng Hospital, Foshan, China.
FAU - Kangfu, Liang
AU  - Kangfu L
AD  - Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical 
      University, Foshan, China.
FAU - Shi-Bin, Wang
AU  - Shi-Bin W
AD  - Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
LA  - eng
PT  - Systematic Review
DEP - 20220523
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC9168239
OTO - NOTNLM
OT  - adverse effects
OT  - autism spectrum disorder
OT  - meta-analysis
OT  - systematic review
OT  - transcranial magnetic stimulation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/10 06:00
MHDA- 2022/06/10 06:01
PMCR- 2022/05/23
CRDT- 2022/06/09 02:24
PHST- 2022/02/14 00:00 [received]
PHST- 2022/04/19 00:00 [accepted]
PHST- 2022/06/09 02:24 [entrez]
PHST- 2022/06/10 06:00 [pubmed]
PHST- 2022/06/10 06:01 [medline]
PHST- 2022/05/23 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.875591 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 May 23;13:875591. doi: 10.3389/fpsyt.2022.875591. 
      eCollection 2022.