PMID- 35677877
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230916
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - Improved Safety of Hybrid Electroconvulsive Therapy Compared With Standard 
      Electroconvulsive Therapy in Patients With Major Depressive Disorder: A 
      Randomized, Double-Blind, Parallel-Group Pilot Trial.
PG  - 896018
LID - 10.3389/fpsyt.2022.896018 [doi]
LID - 896018
AB  - OBJECTIVES: ECT is a rapid and effective treatment for depression. While efficacy 
      is often remarkable over the initial 3-4 sessions, the efficacy of later sessions 
      is less rapid, and the side-effects, especially cognitive impairment limit its 
      use. To preliminarily compare the efficacy and acceptability of a novel 
      hybrid-ECT (HECT) protocol for patients with major depressive disorder (MDD) with 
      standard ECT, we conducted this pilot trial. METHODS: Thirty patients were 
      randomly assigned to ECT or HECT. Both arms received three ECT sessions (phase 1) 
      but, in phase 2, the HECT arm received low-charge electrotherapy instead of ECT. 
      The primary outcome was the change in 24-item Hamilton depression rating scale 
      (HAMD-24) scores between baseline and the end of treatment. Cognitive function 
      was assessed by repeatable battery for the assessment of neuropsychological 
      status (RBANS), Stroop color word, and orientation recovery tests (ORT). Safety 
      was measured by the drop-out rate and adverse events (AEs). Four visits were 
      conducted at baseline, post-phase 1, post-phase 2, and at 1-month follow-up. 
      Trial registration: Chinese Clinical Trial Registry (http://www.chictr.org.cn/), 
      identifier: ChiCTR1900027701. RESULTS: Patients in both arms showed significant 
      within-group improvements in HAMD-24, but the between-group differences were 
      non-significant. Participants in the HECT arm outperformed ECT patients for most 
      cognitive tests at the end of treatment or at follow-up. There was a 
      significantly lower AE rate and shorter ORT in phase 2 of the HECT ar. 
      CONCLUSION: In this pilot trial, HECT was associated with fewer AEs and better 
      cognitive function including executive and memory function, but its possible 
      similar antidepressive efficacy needs to be further investigated in future.
CI  - Copyright (c) 2022 Zhang, Xu, Zeng, Chen, Li, Jiang, Tan, Gu, Lai, Kong, Wang, Rong 
      and Xie.
FAU - Zhang, Jing-Ya
AU  - Zhang JY
AD  - Department of Clinical Psychology, Sleep Medicine Center, Second People's 
      Hospital of Huizhou, Huizhou, China.
FAU - Xu, Shu-Xian
AU  - Xu SX
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Zeng, Lun
AU  - Zeng L
AD  - Department of Clinical Psychology, Sleep Medicine Center, Second People's 
      Hospital of Huizhou, Huizhou, China.
FAU - Chen, Li-Chang
AU  - Chen LC
AD  - Department of Medical Statistics and Epidemiology, School of Public Health, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Li, Jia
AU  - Li J
AD  - Electroconvulsive Therapy Room, Department of Psychosomatic Medicine, Second 
      People's Hospital of Huizhou, Huizhou, China.
FAU - Jiang, Zhao-Yun
AU  - Jiang ZY
AD  - Electroconvulsive Therapy Room, Department of Psychosomatic Medicine, Second 
      People's Hospital of Huizhou, Huizhou, China.
FAU - Tan, Bai-Jian
AU  - Tan BJ
AD  - Department of Clinical Psychology, Sleep Medicine Center, Second People's 
      Hospital of Huizhou, Huizhou, China.
FAU - Gu, Chen-Long
AU  - Gu CL
AD  - Department of Clinical Psychology, Sleep Medicine Center, Second People's 
      Hospital of Huizhou, Huizhou, China.
FAU - Lai, Wen-Tao
AU  - Lai WT
AD  - Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health 
      Center, Shenzhen, China.
FAU - Kong, Xiao-Ming
AU  - Kong XM
AD  - Department of Psychiatry, Anhui Mental Health Center, Hefei, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health 
      Center, Shenzhen, China.
FAU - Rong, Han
AU  - Rong H
AD  - Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health 
      Center, Shenzhen, China.
FAU - Xie, Xin-Hui
AU  - Xie XH
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Brain Function and Psychosomatic Medicine Institute, Second People's Hospital of 
      Huizhou, Huizhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220523
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC9168000
OTO - NOTNLM
OT  - adverse event
OT  - cognitive function
OT  - controlled trial
OT  - double-blind
OT  - electroconvulsive therapy
OT  - hybrid electroconvulsive therapy
OT  - major depressive disorder
OT  - randomized
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/10 06:00
MHDA- 2022/06/10 06:01
PMCR- 2022/05/23
CRDT- 2022/06/09 02:24
PHST- 2022/03/14 00:00 [received]
PHST- 2022/05/02 00:00 [accepted]
PHST- 2022/06/09 02:24 [entrez]
PHST- 2022/06/10 06:00 [pubmed]
PHST- 2022/06/10 06:01 [medline]
PHST- 2022/05/23 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.896018 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 May 23;13:896018. doi: 10.3389/fpsyt.2022.896018. 
      eCollection 2022.