PMID- 35678632
OWN - NLM
STAT- MEDLINE
DCOM- 20220819
LR  - 20220910
IS  - 2050-7895 (Electronic)
IS  - 2050-7887 (Print)
IS  - 2050-7887 (Linking)
VI  - 24
IP  - 8
DP  - 2022 Aug 17
TI  - A food web bioaccumulation model for the accumulation of per- and polyfluoroalkyl 
      substances (PFAS) in fish: how important is renal elimination?
PG  - 1152-1164
LID - 10.1039/d2em00047d [doi]
AB  - Per- and polyfluoroalkyl substances (PFAS) are a large class of highly 
      fluorinated anthropogenic chemicals. Some PFAS bioaccumulate in aquatic food 
      webs, thereby posing risks for seafood consumers. Existing models for persistent 
      organic pollutants (POPs) perform poorly for ionizable PFAS. Here we adapt a 
      well-established food web bioaccumulation model for neutral POPs to predict the 
      bioaccumulation behavior of six perfluoroalkyl acids (PFAAs) and two 
      perfluoroalkyl ether acids (HFPO-DA, 9-Cl-PF3ONS) produced as PFAA replacements. 
      The new model includes sorption to blood plasma proteins and phospholipids, 
      empirically parameterized membrane transport, and renal elimination for PFAAs. 
      Improved performance relative to prior models without these updates is shown by 
      comparing simulations to field and lab measurements. PFAS with eight or more 
      perfluorinated carbons (eta(pfc) >/= 8, i.e., C8 perfluorosulfonic acid, C10-C11 
      perfluorocarboxylic acid, 9-Cl-PF3ONS) are often the most abundant in aquatic 
      food webs. The new model reproduces their observed bioaccumulation potential 
      within a factor of two for >80% of fish species, indicating its readiness to 
      support development of fish consumption advisories for these compounds. Results 
      suggest bioaccumulation of eta(pfc) >/= 8 PFAS is primarily driven by phospholipid 
      partitioning, and that renal elimination is negligible for these compounds. 
      However, specific protein binding mechanisms are important for reproducing the 
      observed tissue concentrations of many shorter-chain PFAAs, including protein 
      transporter-mediated renal elimination. Additional data on protein-binding and 
      membrane transport mechanisms for PFAS are needed to better understand the 
      biological behavior of shorter-chain PFAAs and their alternatives.
FAU - Sun, Jennifer M
AU  - Sun JM
AUID- ORCID: 0000-0001-9985-0408
AD  - Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard 
      University, Cambridge, MA, USA, 02138. jennifersun@.g.harvard.edu.
FAU - Kelly, Barry C
AU  - Kelly BC
AUID- ORCID: 0000-0002-3449-6310
AD  - Meta Analytical Inc., Calgary, AB, T3H 2Z5, Canada.
AD  - School of Resource and Environmental Management, Faculty of the Environment, 
      Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
FAU - Gobas, Frank A P C
AU  - Gobas FAPC
AD  - School of Resource and Environmental Management, Faculty of the Environment, 
      Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
FAU - Sunderland, Elsie M
AU  - Sunderland EM
AUID- ORCID: 0000-0003-0386-9548
AD  - Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard 
      University, Cambridge, MA, USA, 02138. jennifersun@.g.harvard.edu.
LA  - eng
GR  - P42 ES027706/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20220817
PL  - England
TA  - Environ Sci Process Impacts
JT  - Environmental science. Processes & impacts
JID - 101601576
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - *Alkanesulfonic Acids/metabolism
MH  - Animals
MH  - Bioaccumulation
MH  - Fishes/metabolism
MH  - *Fluorocarbons/analysis
MH  - Food Chain
MH  - Renal Elimination
MH  - *Water Pollutants, Chemical/metabolism
PMC - PMC9384792
COIS- There are no conflicts to declare.
EDAT- 2022/06/10 06:00
MHDA- 2022/08/20 06:00
PMCR- 2022/05/25
CRDT- 2022/06/09 09:33
PHST- 2022/06/10 06:00 [pubmed]
PHST- 2022/08/20 06:00 [medline]
PHST- 2022/06/09 09:33 [entrez]
PHST- 2022/05/25 00:00 [pmc-release]
AID - d2em00047d [pii]
AID - 10.1039/d2em00047d [doi]
PST - epublish
SO  - Environ Sci Process Impacts. 2022 Aug 17;24(8):1152-1164. doi: 
      10.1039/d2em00047d.