PMID- 35679736
OWN - NLM
STAT- MEDLINE
DCOM- 20220831
LR  - 20220831
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 217
DP  - 2022 Sep
TI  - Temperature/pH-responsive carmofur-loaded nanogels rapidly prepared via one-pot 
      laser-induced emulsion polymerization.
PG  - 112611
LID - S0927-7765(22)00294-6 [pii]
LID - 10.1016/j.colsurfb.2022.112611 [doi]
AB  - Tumor microenvironment-responsive nanogels loading antitumor drugs can improve 
      the chemotherapy efficiency due to their suitable size, great hydrophilicity, 
      excellent biocompatibility, and sensitivity to specific stimulation. Herein, a 
      simple and effective strategy of one-pot laser-induced emulsion polymerization at 
      532 nm was developed to prepare carmofur-loaded nanogels based on biocompatible 
      and temperature/pH-sensitive monomers including polyethylene glycol diacrylate 
      (PEGDA), N-vinylcaprolactam (NVCL), and 2-(dimethylamino) ethyl methacrylate 
      (DMAEMA). The nanogels loading carmofur with dual-stimuli responsive drug release 
      properties were rapidly obtained under laser irradiation (beam diameter 2.5 mm, 
      laser power 60 mW) for only 100 s. These nanogels exhibited an average 
      hydrodynamic diameter of 195.9 nm and a low polydispersity index of 0.115. The 
      effect of monomer ratio on the size, morphology, double-bond conversion, and 
      thermo/pH-sensitivity of nanogels was investigated. The cumulative carmofur 
      release from nanogels at pH 5.0 within 48 h was nearly three times that at pH 
      7.4, while the release amount at 42  degrees C was twice that at 25  degrees C, showing the 
      controlled and sustainable release with the change of pH and temperature. The in 
      vitro release kinetics of carmofur was in accord with first-order release model.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Du, Xinjing
AU  - Du X
AD  - School of Chemical Engineering and Technology, Tianjin University, Tianjin 
      300350, China.
FAU - Peng, Yuanyuan
AU  - Peng Y
AD  - School of Chemical Engineering and Technology, Tianjin University, Tianjin 
      300350, China.
FAU - Zhao, Chunyue
AU  - Zhao C
AD  - School of Chemical Engineering and Technology, Tianjin University, Tianjin 
      300350, China.
FAU - Xing, Jinfeng
AU  - Xing J
AD  - School of Chemical Engineering and Technology, Tianjin University, Tianjin 
      300350, China. Electronic address: jinfengxing@tju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220606
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsions)
RN  - 0 (Nanogels)
RN  - HA82M3RAB2 (carmofur)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Drug Carriers/chemistry
MH  - Emulsions
MH  - *Fluorouracil/analogs & derivatives
MH  - Hydrogen-Ion Concentration
MH  - *Lasers
MH  - Nanogels
MH  - Polymerization
MH  - Temperature
OTO - NOTNLM
OT  - Carmofur
OT  - Controlled drug release
OT  - Laser-induced emulsion polymerization
OT  - Nanogels
OT  - Temperature/pH-responsive
EDAT- 2022/06/10 06:00
MHDA- 2022/09/01 06:00
CRDT- 2022/06/09 18:19
PHST- 2022/04/01 00:00 [received]
PHST- 2022/05/05 00:00 [revised]
PHST- 2022/06/02 00:00 [accepted]
PHST- 2022/06/10 06:00 [pubmed]
PHST- 2022/09/01 06:00 [medline]
PHST- 2022/06/09 18:19 [entrez]
AID - S0927-7765(22)00294-6 [pii]
AID - 10.1016/j.colsurfb.2022.112611 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2022 Sep;217:112611. doi: 
      10.1016/j.colsurfb.2022.112611. Epub 2022 Jun 6.