PMID- 35679738
OWN - NLM
STAT- MEDLINE
DCOM- 20220622
LR  - 20220724
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 165
DP  - 2022 Jul
TI  - Individual and mixed metal maternal blood concentrations in relation to birth 
      size: An analysis of the Japan Environment and Children's Study (JECS).
PG  - 107318
LID - S0160-4120(22)00245-8 [pii]
LID - 10.1016/j.envint.2022.107318 [doi]
AB  - BACKGROUND: Growth restriction in the prenatal period is a significant public 
      health concern. Metals can negatively affect birth size, and pregnant women may 
      be exposed to metal mixtures. Comprehensive studies analyzing the effects of 
      combined metal exposure with accurate individual blood metal concentrations are 
      limited. The current study investigated the associations between maternal metal 
      exposure and birth size in a large, nationwide Japanese cohort using individual 
      and mixed model approaches. METHODS: Lead, cadmium, mercury, selenium, and 
      manganese blood concentrations were measured in pregnant women in the Japan 
      Environment and Children's Study (JECS). Measurements of infant birth 
      size-including body weight, body length, and head and chest circumference-were 
      collected. Linear and logistic regressions were used for birth size measurements 
      and the odds of an infant being small in size for gestational age, respectively. 
      Associations between combined metal mixtures and measurements at birth were 
      evaluated using quantile g-computation and Bayesian kernel machine regression 
      (BKMR). RESULTS: Of the 103,060 JECS pregnancies, 93,739 mother-infant pairs were 
      analyzed. The linear regression models showed that lead, selenium, cadmium, and 
      manganese-but not mercury-were associated with body weight. Cadmium was 
      associated with length and chest circumference and mercury was associated with 
      head circumference. Quantile g-computation revealed that manganese increased 
      infant birth weight, length, head circumference, and chest circumference. Lead 
      was the strongest negative factor for infant birth weight, length, head 
      circumference, and chest circumference. The BKMR analysis revealed that the 
      metals had an additive, rather than a synergistic effect. CONCLUSION: Metal 
      exposure is associated with infant birth size, with lead and manganese playing a 
      more significant role in Japan. The effects of prenatal combined metal exposure 
      at low levels warrant public health attention.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Takatani, Tomozumi
AU  - Takatani T
AD  - Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, 
      Japan. Electronic address: t-takatani@chiba-u.jp.
FAU - Eguchi, Akifumi
AU  - Eguchi A
AD  - Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.
FAU - Yamamoto, Midori
AU  - Yamamoto M
AD  - Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.
FAU - Sakurai, Kenichi
AU  - Sakurai K
AD  - Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.
FAU - Takatani, Rieko
AU  - Takatani R
AD  - Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.
FAU - Taniguchi, Yu
AU  - Taniguchi Y
AD  - Japan Environment and Children's Study Programme Office, National Institute for 
      Environmental Studies, Ibaraki, Japan.
FAU - Nakayama, Shoji F
AU  - Nakayama SF
AD  - Japan Environment and Children's Study Programme Office, National Institute for 
      Environmental Studies, Ibaraki, Japan.
FAU - Mori, Chisato
AU  - Mori C
AD  - Center for Preventive Medical Sciences, Chiba University, Chiba, Japan; 
      Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Kamijima, Michihiro
AU  - Kamijima M
AD  - Department of Occupational and Environmental Health, Nagoya City University, 
      Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: 
      kamijima@med.nagoya-cu.ac.jp.
CN  - Japan Environment and Children's Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220523
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Metals)
RN  - 00BH33GNGH (Cadmium)
RN  - 42Z2K6ZL8P (Manganese)
RN  - FXS1BY2PGL (Mercury)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Bayes Theorem
MH  - Birth Weight
MH  - Cadmium
MH  - Child
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Japan
MH  - Manganese
MH  - Maternal Exposure/adverse effects
MH  - *Mercury
MH  - Metals
MH  - Pregnancy
MH  - *Selenium
OTO - NOTNLM
OT  - Low birth weight
OT  - Metal
OT  - Prenatal period
OT  - Small for gestational age
EDAT- 2022/06/10 06:00
MHDA- 2022/06/23 06:00
CRDT- 2022/06/09 18:20
PHST- 2021/11/03 00:00 [received]
PHST- 2022/05/15 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/06/10 06:00 [pubmed]
PHST- 2022/06/23 06:00 [medline]
PHST- 2022/06/09 18:20 [entrez]
AID - S0160-4120(22)00245-8 [pii]
AID - 10.1016/j.envint.2022.107318 [doi]
PST - ppublish
SO  - Environ Int. 2022 Jul;165:107318. doi: 10.1016/j.envint.2022.107318. Epub 2022 
      May 23.