PMID- 35680746
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230404
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 51
DP  - 2022 Nov
TI  - Investigating associations between urinary phthalate metabolite concentrations 
      and chronic diarrhea: findings from the National Health and Nutrition Examination 
      Survey, 2005-2010.
PG  - 77625-77634
LID - 10.1007/s11356-022-21123-y [doi]
AB  - This study aimed to explore the relationship between chronic diarrhea and urinary 
      phthalate metabolite concentrations in US adults from the 2005-2010 NHANES study. 
      After adjusting for potential confounding factors, logistic regression was used 
      to explore the relationship between phthalates (PAEs) concentrations and chronic 
      diarrhea, Bayesian kernel machine regression (BKMR), and quantile g calculation 
      (quantile-based g calculation, qgcomp) which was used to study the combined and 
      independent effects of PAEs on gastrointestinal infections. In the current study, 
      4260 adult participants over the age of 20 from the NHANES study were included, 
      of whom 542 (12.72%) were assessed as having chronic diarrhea. In multivariate 
      logistic regression analysis, after adjusting for all relevant covariates, the 
      results showed that urinary phthalate metabolite concentrations were 
      significantly associated with the risk of chronic diarrhea (P<0.001). Various 
      PAEs were risk factors for chronic diarrhea, among which MiBP (OR=1.419, 95% CI: 
      1.416-1.423) and MCPP (OR=1.237, 95% CI: 1.235-1.239) were more significant. The 
      BKME results showed a significant increase in the risk of chronic diarrhea with 
      increasing total levels of the PAEs mixture. Mixed exposure to PAEs can promote 
      the occurrence of chronic diarrhea, and the effect was more pronounced in obese 
      people. Notably, most PAEs showed some degree of protection in overweight people. 
      The risk effect of PAEs was more significant in the middle-aged and older 
      population than in the younger population.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Ren, Weirui
AU  - Ren W
AD  - Department of Gastroenterology, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China.
FAU - Zhang, Chuang
AU  - Zhang C
AD  - Department of Pediatric Surgery, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China.
FAU - Wang, Xiaoya
AU  - Wang X
AD  - Undergraduate of Jitang College, The North China University of Science and 
      Technology, Tangshan, China.
FAU - Wang, Junmin
AU  - Wang J
AD  - Department of Gastroenterology, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China. somatostatin@126.com.
LA  - eng
PT  - Journal Article
DEP - 20220609
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Humans
MH  - Middle Aged
MH  - Bayes Theorem
MH  - Diarrhea/epidemiology
MH  - Environmental Exposure/analysis
MH  - *Environmental Pollutants/analysis
MH  - Nutrition Surveys
MH  - *Phthalic Acids/toxicity
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Chronic diarrhea
OT  - NHANES
OT  - Phthalate metabolite
OT  - Quantile g-computation
EDAT- 2022/06/11 06:00
MHDA- 2022/10/22 06:00
CRDT- 2022/06/10 00:07
PHST- 2022/04/26 00:00 [received]
PHST- 2022/05/23 00:00 [accepted]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/10/22 06:00 [medline]
PHST- 2022/06/10 00:07 [entrez]
AID - 10.1007/s11356-022-21123-y [pii]
AID - 10.1007/s11356-022-21123-y [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Nov;29(51):77625-77634. doi: 
      10.1007/s11356-022-21123-y. Epub 2022 Jun 9.