PMID- 35681217
OWN - NLM
STAT- MEDLINE
DCOM- 20220613
LR  - 20220827
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 21
IP  - 1
DP  - 2022 Jun 9
TI  - Atrioventricular coupling and left atrial abnormality in type 2 diabetes mellitus 
      with functional mitral regurgitation patients verified by cardiac magnetic 
      resonance imaging.
PG  - 100
LID - 10.1186/s12933-022-01536-2 [doi]
LID - 100
AB  - BACKGROUND: Functional mitral regurgitation (FMR) in type 2 diabetes mellitus 
      (T2DM) patients induced by left ventricular (LV) enlargement and mitral valve 
      abnormality may aggravated the impairment in left atrial (LA) compliance. Thus, 
      this study aimed to depict how FMR and LV dysfunction affect LA compliance in 
      T2DM patients with FMR. MATERIALS AND METHODS: A total of 148 patients with T2DM 
      and 49 age- and sex-matched normal controls underwent cardiac magnetic resonance 
      examination. LA longitudinal strain and LA and LV functional indices were 
      compared among controls and different T2DM patients. The multivariate analysis 
      was used to identify the independent indicators of LA longitudinal strain. 
      RESULTS: T2DM Patients without FMR had a lower total LA empty fraction (LAEF) 
      compared with the controls (all P < 0.05). T2DM patients with mild and moderate 
      FMR showed increased LA volume (LAV) and LV volume while decreased LAEF, LA 
      strain, and LV ejection fraction (P < 0.05). T2DM patients with severe FMR showed 
      markedly increased LAV and LV volume while decreased LAEF, LA strain, and LVEF 
      (P < 0.05). In T2DM patients with FMR, reservoir strain (epsilons) was independently 
      correlated with LV end-diastolic volume (LVEDV) (beta = - 0.334) and regurgitation 
      degree (beta = - 0.256). The passive strain (epsilone) was independently correlated with 
      regurgitation degree (beta = - 0.297), whereas the active strain (epsilona) was 
      independently correlated with LVESV (beta = - 0.352) and glycated haemoglobin 
      (beta = - 0.279). CONCLUSION: FMR may aggravate LA and LV dysfunction in T2DM 
      patients. Regurgitation degree was an independent determinant of the epsilons and the 
      epsilone, LVEDV was an independent determinant of the epsilons, and LVESV was an independent 
      determinant of the epsilona in T2DM patients with FMR.
CI  - (c) 2022. The Author(s).
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
AD  - Department of Radiology, School of Medicine, Sichuan Cancer Hospital and 
      Institute, Sichuan Cancer Center, University of Electronic Science and Technology 
      of China, 55# Lan 4 RenMing Road (South), Chengdu, 610041, Sichuan, China.
FAU - Li, Xue-Ming
AU  - Li XM
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
AD  - Department of Radiology, School of Medicine, Sichuan Cancer Hospital and 
      Institute, Sichuan Cancer Center, University of Electronic Science and Technology 
      of China, 55# Lan 4 RenMing Road (South), Chengdu, 610041, Sichuan, China.
FAU - Shen, Meng-Ting
AU  - Shen MT
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Huang, Shan
AU  - Huang S
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China. yangzg666@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220609
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - Hypertrophy, Left Ventricular
MH  - Magnetic Resonance Imaging
MH  - *Mitral Valve Insufficiency/diagnostic imaging/etiology
MH  - Stroke Volume
MH  - *Ventricular Dysfunction, Left/diagnostic imaging/etiology
MH  - Ventricular Function, Left
PMC - PMC9185866
OTO - NOTNLM
OT  - Atrioventricular coupling
OT  - Cardiac magnetic resonance
OT  - Functional mitral regurgitation
OT  - Type 2 diabetes mellitus
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/14 06:00
PMCR- 2022/06/09
CRDT- 2022/06/10 00:39
PHST- 2022/04/21 00:00 [received]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/06/10 00:39 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/14 06:00 [medline]
PHST- 2022/06/09 00:00 [pmc-release]
AID - 10.1186/s12933-022-01536-2 [pii]
AID - 1536 [pii]
AID - 10.1186/s12933-022-01536-2 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2022 Jun 9;21(1):100. doi: 10.1186/s12933-022-01536-2.