PMID- 35681640
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221126
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 11
DP  - 2022 May 27
TI  - Tropomyosin-Related Kinase Fusions in Gastrointestinal Stromal Tumors.
LID - 10.3390/cancers14112659 [doi]
LID - 2659
AB  - The canonical mutations in gastrointestinal stromal tumors (GISTs) are typically 
      activating mutations in KIT and platelet-derived growth factor receptor alpha 
      (PDGFRA). GISTs with non-canonical mutations are a heterogeneous group. Here, we 
      examined tropomyosin-related kinase (TRK) fusion in GIST cases without KIT/PDGFRA 
      mutations (KIT/PDGFRA wild-type (WT) GISTs). We retrospectively analyzed patients 
      who were diagnosed with GISTs at the Yonsei Cancer Center, Severance Hospital, 
      between January 1998 and December 2016. Thirty-one patients with KIT/PDGFRA WT 
      GISTs were included in the analysis. TRK expression in tumor samples was assessed 
      by pan-TRK immunohistochemistry (IHC), and the neurotrophic tyrosine receptor 
      kinase (NTRK: the gene encoding TRK) rearrangement was analyzed by fluorescence 
      in situ hybridization (FISH). IHC analyses revealed that five cases in this 
      cohort exhibited a weak to moderate TRK expression. NTRK1 fusions were detected 
      in three tumor samples, and two samples harbored NTRK3 fusions. The remaining 26 
      samples did not harbor NTRK fusions. Two types of NTRK fusions were detected, and 
      the overall NTRK fusion frequency in KIT/PDGFRA WT GIST cases was 16% (5/31). Our 
      data provide insights into the molecular alterations underpinning KIT/PDGFRA WT 
      GISTs. More effort should be devoted to improve methods to identify this distinct 
      disease subtype within the KIT/PDGFRA WT GIST group.
FAU - Lee, Ji Hyun
AU  - Lee JH
AD  - Department of Internal Medicine, Division of Medical Oncology, Eunpyeong St. 
      Mary's Hospital, The Catholic University of Korea, Seoul 03312, Korea.
FAU - Shin, Su-Jin
AU  - Shin SJ
AUID- ORCID: 0000-0001-9114-8438
AD  - Department of Pathology, Gangnam Severance Hospital, Yonsei University College of 
      Medicine, Seoul 06273, Korea.
FAU - Choe, Eun-Ah
AU  - Choe EA
AD  - Department of Internal Medicine, Division of Hospital Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
FAU - Kim, Jungyoun
AU  - Kim J
AD  - Department of Medicine, Yonsei University College of Medicine, Seoul 03722, 
      Korea.
AD  - Songdang Institute for Cancer Research, Yonsei University College of Medicine, 
      Seoul 03722, Korea.
FAU - Hyung, Woo Jin
AU  - Hyung WJ
AUID- ORCID: 0000-0002-8593-9214
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Kim, Hyo Song
AU  - Kim HS
AD  - Yonsei Cancer Center, Department of Internal Medicine, Division of Medical 
      Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Jung, Minkyu
AU  - Jung M
AD  - Yonsei Cancer Center, Department of Internal Medicine, Division of Medical 
      Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Beom, Seung-Hoon
AU  - Beom SH
AD  - Yonsei Cancer Center, Department of Internal Medicine, Division of Medical 
      Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Kim, Tae Il
AU  - Kim TI
AUID- ORCID: 0000-0003-4807-890X
AD  - Department of Internal Medicine, Institute of Gastroenterology, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
FAU - Ahn, Joong Bae
AU  - Ahn JB
AD  - Yonsei Cancer Center, Department of Internal Medicine, Division of Medical 
      Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Chung, Hyun Cheol
AU  - Chung HC
AD  - Yonsei Cancer Center, Department of Internal Medicine, Division of Medical 
      Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Shin, Sang Joon
AU  - Shin SJ
AD  - Yonsei Cancer Center, Department of Internal Medicine, Division of Medical 
      Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.
LA  - eng
PT  - Journal Article
DEP - 20220527
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
EIN - Cancers (Basel). 2022 Nov 17;14(22):. PMID: 36428814
PMC - PMC9179593
OTO - NOTNLM
OT  - KIT
OT  - PDGF receptor tyrosine kinase
OT  - gastrointestinal stromal tumor
OT  - neurotrophic tyrosine receptor kinase fusion
OT  - tropomyosin-related kinase fusion
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/11 06:01
PMCR- 2022/05/27
CRDT- 2022/06/10 01:08
PHST- 2022/03/24 00:00 [received]
PHST- 2022/05/23 00:00 [revised]
PHST- 2022/05/24 00:00 [accepted]
PHST- 2022/06/10 01:08 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/11 06:01 [medline]
PHST- 2022/05/27 00:00 [pmc-release]
AID - cancers14112659 [pii]
AID - cancers-14-02659 [pii]
AID - 10.3390/cancers14112659 [doi]
PST - epublish
SO  - Cancers (Basel). 2022 May 27;14(11):2659. doi: 10.3390/cancers14112659.