PMID- 35681845
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 12
IP  - 11
DP  - 2022 May 27
TI  - Research Progress in Porcine Reproductive and Respiratory Syndrome Virus-Host 
      Protein Interactions.
LID - 10.3390/ani12111381 [doi]
LID - 1381
AB  - Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious 
      disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), 
      which has been regarded as a persistent challenge for the pig industry in many 
      countries. PRRSV is internalized into host cells by the interaction between PRRSV 
      proteins and cellular receptors. When the virus invades the cells, the host 
      antiviral immune system is quickly activated to suppress the replication of the 
      viruses. To retain fitness and host adaptation, various viruses have evolved 
      multiple elegant strategies to manipulate the host machine and circumvent against 
      the host antiviral responses. Therefore, identification of virus-host 
      interactions is critical for understanding the host defense against viral 
      infections and the pathogenesis of the viral infectious diseases. Most viruses, 
      including PRRSV, interact with host proteins during infection. On the one hand, 
      such interaction promotes the virus from escaping the host immune system to 
      complete its replication. On the other hand, the interactions regulate the host 
      cell immune response to inhibit viral infections. As common antiviral drugs 
      become increasingly inefficient under the pressure of viral selectivity, 
      therapeutic agents targeting the intrinsic immune factors of the host protein are 
      more promising because the host protein has a lower probability of mutation under 
      drug-mediated selective pressure. This review elaborates on the virus-host 
      interactions during PRRSV infection to summarize the pathogenic mechanisms of 
      PRRSV, and we hope this can provide insights for designing effective vaccines or 
      drugs to prevent and control the spread of PRRS.
FAU - Zhang, Hang
AU  - Zhang H
AD  - School of Life Science and Engineering, Foshan University, Foshan 528000, China.
AD  - Veterinary Teaching Hospital, Foshan University, Foshan 528000, China.
FAU - Sha, Huiyang
AU  - Sha H
AD  - School of Life Science and Engineering, Foshan University, Foshan 528000, China.
AD  - Veterinary Teaching Hospital, Foshan University, Foshan 528000, China.
FAU - Qin, Limei
AU  - Qin L
AD  - School of Life Science and Engineering, Foshan University, Foshan 528000, China.
AD  - Veterinary Teaching Hospital, Foshan University, Foshan 528000, China.
FAU - Wang, Nina
AU  - Wang N
AD  - School of Life Science and Engineering, Foshan University, Foshan 528000, China.
AD  - Veterinary Teaching Hospital, Foshan University, Foshan 528000, China.
FAU - Kong, Weili
AU  - Kong W
AUID- ORCID: 0000-0002-9104-7730
AD  - Gladstone Institutes of Virology and Immunology, University of California, San 
      Francisco, CA 94158, USA.
FAU - Huang, Liangzong
AU  - Huang L
AD  - School of Life Science and Engineering, Foshan University, Foshan 528000, China.
AD  - Veterinary Teaching Hospital, Foshan University, Foshan 528000, China.
FAU - Zhao, Mengmeng
AU  - Zhao M
AD  - School of Life Science and Engineering, Foshan University, Foshan 528000, China.
AD  - Veterinary Teaching Hospital, Foshan University, Foshan 528000, China.
LA  - eng
GR  - 31902279/National Natural Science Foundation of China/
GR  - 31902284/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20220527
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC9179581
OTO - NOTNLM
OT  - host protein
OT  - interaction
OT  - porcine reproductive and respiratory syndrome virus
OT  - research progress
OT  - viral pathogenesis
COIS- The authors declare that they have no competing interests.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/11 06:01
PMCR- 2022/05/27
CRDT- 2022/06/10 01:10
PHST- 2022/04/25 00:00 [received]
PHST- 2022/05/25 00:00 [revised]
PHST- 2022/05/26 00:00 [accepted]
PHST- 2022/06/10 01:10 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/11 06:01 [medline]
PHST- 2022/05/27 00:00 [pmc-release]
AID - ani12111381 [pii]
AID - animals-12-01381 [pii]
AID - 10.3390/ani12111381 [doi]
PST - epublish
SO  - Animals (Basel). 2022 May 27;12(11):1381. doi: 10.3390/ani12111381.