PMID- 35682857
OWN - NLM
STAT- MEDLINE
DCOM- 20220613
LR  - 20240102
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 11
DP  - 2022 May 31
TI  - The Pyroptosis-Related Gene Prognostic Index Associated with Tumor Immune 
      Infiltration for Pancreatic Cancer.
LID - 10.3390/ijms23116178 [doi]
LID - 6178
AB  - Pancreatic cancer (PC) is one of the most fatal malignancies. Pyroptosis, a type 
      of inflammatory cell death, likely plays a critical role in the development and 
      progression of tumors. However, the relationship between pyroptosis-related genes 
      (PRGs) and prognosis and immunity to PC is not entirely clear. This study, aimed 
      at identifying the key PRGs in PC, highlights their prognostic value, immune 
      characteristics, and candidate drugs for therapies. We screened 47 differentially 
      expressed PRGs between PC and normal pancreas tissues from The Cancer Genome 
      Atlas (TCGA) and Genotype-Tissue Expression (GTEx) datasets. Afterwards, a 
      pyroptosis-related gene prognostic index (PRGPI) was constructed based on eight 
      PRGs (AIM2, GBP1, HMGB1, IL18, IRF6, NEK7, NLRP1 and PLCG1) selected by 
      univariate and multivariate Cox regression analysis and LASSO regression 
      analysis, and verified in two external datasets from the International Cancer 
      Genome Consortium (ICGC) and Gene Expression Omnibus (GEO) databases. We found 
      that the PC patients in the PRGPI-defined subgroups not only reflected 
      significantly different levels of infiltration in a variety of immune cells, such 
      as M1 macrophages, but also showed differential expression in genes of the human 
      leukocyte antigen (HLA) family and immune checkpoints. Additionally, molecular 
      characteristics and drug sensitivity also stayed close to the PRGPI risk scores. 
      Therefore, PRGPI may serve as a valuable prognostic biomarker and may potentially 
      provide guidance toward novel therapeutic options for PC patients.
FAU - Xie, Wen
AU  - Xie W
AUID- ORCID: 0000-0003-2455-4748
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
FAU - Li, Xiaoyi
AU  - Li X
AUID- ORCID: 0000-0002-3725-259X
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
FAU - Yang, Chunxiu
AU  - Yang C
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
FAU - Li, Jiahao
AU  - Li J
AUID- ORCID: 0000-0001-6437-1562
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
FAU - Shen, Guoyan
AU  - Shen G
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
FAU - Chen, Hongshan
AU  - Chen H
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
FAU - Xiao, Shu-Yuan
AU  - Xiao SY
AD  - Department of Pathology, University of Chicago Medicine, Chicago, IL 60637, USA.
FAU - Li, Yueying
AU  - Li Y
AD  - Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan 430000, China.
AD  - Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan 430000, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220531
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (IRF6 protein, human)
RN  - 0 (Interferon Regulatory Factors)
SB  - IM
MH  - Humans
MH  - Interferon Regulatory Factors/metabolism
MH  - *Pancreatic Neoplasms/genetics/metabolism
MH  - Prognosis
MH  - *Pyroptosis/genetics
MH  - Risk Factors
PMC - PMC9180955
OTO - NOTNLM
OT  - immune infiltration
OT  - pancreatic cancer
OT  - prognostic index
OT  - pyroptosis-related gene
OT  - therapy
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/14 06:00
PMCR- 2022/05/31
CRDT- 2022/06/10 01:15
PHST- 2022/05/10 00:00 [received]
PHST- 2022/05/27 00:00 [revised]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/06/10 01:15 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/14 06:00 [medline]
PHST- 2022/05/31 00:00 [pmc-release]
AID - ijms23116178 [pii]
AID - ijms-23-06178 [pii]
AID - 10.3390/ijms23116178 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 May 31;23(11):6178. doi: 10.3390/ijms23116178.